Figure 4

Genomic organisation of ISG12 genes in humans and mice showing ISRE positions. Regions of human chromosomes 1p35 and 14q32, and mouse chromosome 12F1, carrying ISG12 genes are shown. Transcribed regions are coloured (thickened lines, introns; boxes, exons) and arrows represent direction of transcription. Translational initiation and termination sites are indicated by green and red circles, respectively. Exons encoding an ISG12 motif are starred. The positions of numbered ISRE sequences (as defined in Table 2) are indicated. Orientations relative to Telomeres (TEL) and Centromeres (CEN) are indicated. The regions shown can be accessed from the Ensembl website using the following addresses: http://www.ensembl.org/Homo_sapiens/contigview?chr=1&vc_start=27575333&vc_end=27625333&highlight=ENSG00000126709; http://www.ensembl.org/Homo_sapiens/contigview?chr=14&vc_start=92535062&vc_end=92590000&x=0&y=0; http://www.ensembl.org/Mus_musculus/contigview?chr=12&vc_start=97445000&vc_end=97475000&x=38&y=12.