Sequence comparison of the human Sp8 protein with those from other invertebrate species; red flour beetle, Tribolium castaneum, TcSp8 and fruit fly, Drosophila melanogaster Sp8, DmD-Sp1 proteins. The locations of the exon/exon boundaries are underlined in black on the protein sequences (GE and S). The methionine residues at the start of translation for the short protein isoforms are underlined in red (M). The positions of the Sp, BTD-box and three zinc-fingers motifs are shown. Stop codons are indicated by a hash.