Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: The Human GPCR-DB Database

Table 2 Number of GPCRs in validated and non-validated categories.

Nr. of GPCR genes	Total nsSNPS	Validated nsSNPs	Non-validated nsSNPs	This study
338 (genes classified as GPCRs)	392	181	211 (123 were considered for validation).	80 of 123 assayed. 20 were polymorphic
222 (bearing evidence for 7-TM domains)	283	112 (Added 120 from [16])	171
101 (classified in 3 sub-groups – Monoamine, Peptide and Chemokine).	182	53 (Added 83 from [16]) = 136 (used in Table 3).

The initial 338 GPCRs were selected as per annotation by Ensembl. Support for structural evidence of 222 GPCRs was obtained from SWISSPROT. Classification of GPCRs was obtained from GPCRDB http://www.gpcr.org/7tm, Ensembl http://www.ensembl.org, International Union of Pharmacology http://www.iuphar.org.

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