TY - JOUR AU - Rachlin, John AU - Ding, Chunming AU - Cantor, Charles AU - Kasif, Simon PY - 2005 DA - 2005/07/25 TI - Computational tradeoffs in multiplex PCR assay design for SNP genotyping JO - BMC Genomics SP - 102 VL - 6 IS - 1 AB - Multiplex PCR is a key technology for detecting infectious microorganisms, whole-genome sequencing, forensic analysis, and for enabling flexible yet low-cost genotyping. However, the design of a multiplex PCR assays requires the consideration of multiple competing objectives and physical constraints, and extensive computational analysis must be performed in order to identify the possible formation of primer-dimers that can negatively impact product yield. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-6-102 DO - 10.1186/1471-2164-6-102 ID - Rachlin2005 ER -