Table 1 List of GPCRs in each of the 32 clusters derived from phylogenetic analysis. Suffix _Hum and _Dro refers to human and Drosophila sequences respectively. Orphan receptors are shown in bold.
CLUSTER 1 | CLUSTER 2 | CLUSTER 3 | CLUSTER 4 | CLUSTER 5 | CLUSTER 6 | CLUSTER 7 | CLUSTER 8 | |
|---|---|---|---|---|---|---|---|---|
GALR_Hum | GPR7_Hum | AG22_Hum | BRS3_Hum | GHSR_Hum | Q9VFW6_Dro | GP19_Hum | FSHR_Hum | CCKR_Hum |
GALS_Hum | GPR8_Hum | AG2R_Hum | ET1R_Hum | GP39_Hum | Q9VP15_Dro | GRHR_Hum | LGR4_Hum | GASR_Hum |
GALT_Hum | OPRD_Hum | APJ_Hum | ETB2_Hum | MTLR_Hum | Q9VT27_Dro | GRR2_Hum | LGR5_Hum | NFF1_Hum |
GP24_Hum | OPRK_Hum | BRB1_Hum | ETBR_Hum | NTR1_Hum | Q9W025_Dro | GRHR_Dro | LGR6_Hum | NFF2_Hum |
Q969F8_Hum | OPRM_Hum | BRB2_Hum | GP37_Hum | NTR2_Hum | Q9W027_Dro | OXYR_Hum | LGR7_Hum | OX1R_Hum |
Q969V1_Hum | OPRX_Hum | GP15_Hum | GRPR_Hum | NMU1R_Hum | Q9W4H3_Dro | GRHRII_Dro | LGR8_Hum | OX2R_Hum |
Q9NBC8_Dro | Q8I943_Dro | GP25_Hum | NMBR_Hum | NMU2R_Hum | TRFR_Hum | Q8ITD2_Dro | LSHR_Hum | Q14439_Hum |
Q9U721_Dro | Q8ISJ9_Dro | Q8NGZ8_Hum | Q8TDV0_Hum | Q8ITC7_Dro | Â | Q8NGU9_Hum | Q8SX01_Dro | GPR103_Hum |
SAPR_Hum | SSR1_Hum | Â | Q9V858_Dro | Q8ITC9_Dro | Â | V1AR_Hum | Q9NDI1_Dro | Q8MKU0_Dro |
UR2R_Hum | SSR2_Hum | Â | Q9V9K3_Dro | Q8SWR3_Dro | Â | V1BR_Hum | Q9VBP0_Dro | Q9VWQ9_Dro |
| Â | SSR3_Hum | Â | Â | Q9V5T1_Dro | Â | V2R_Hum | Q9VYG0_Dro | Q9VWR3_Dro |
| Â | SSR4_Hum | Â | Â | Q9VDC4_Dro | Â | Â | TSHR_Hum | Â |
| Â | SSR5_Hum | Â | Â | Q9VFW5_Dro | Â | Â | Â | Â |
CLUSTER 9 | CLUSTER 10 | CLUSTER 11 | CLUSTER 12 | CLUSTER 13 | CLUSTER 14 | CLUSTER 15 | CLUSTER 16 | CLUSTER 17 |
C3AR_Hum | MAS_Hum | GP10_Hum | C3X1_Hum | ADMR_Hum | OPN3_Hum | CLT1_Hum | GP34_Hum | ACTR_Hum |
C5AR_Hum | MRG_Hum | GP72_Hum | CKD6_Hum | CCR3_Hum | OPN4_Hum | CLT2_Hum | H963_Hum | CB1R_Hum |
C5L2_Hum | MRGF_Hum | NK1R_Hum | CKR1_Hum | CCR4_Hum | OPS1_Dro | GP17_Hum | P2YC_Hum | CB2R_Hum |
CML1_Hum | Q8NGK7_Hum | NK2R_Hum | CKR2_Hum | CCR5_Hum | OPS2_Dro | GP31_Hum | P2YX_Hum | EDG2_Hum |
FML1_Hum | Q8TDD6_Hum | NK3R_Hum | CKR3_Hum | CCR6_Hum | OPS3_Dro | GP40_Hum | PAFR_Hum | EDG3_Hum |
FML2_Hum | Q8TDD8_Hum | NK4R_Hum | CKR4_Hum | CKR6_Hum | OPS4_Dro | GP41_Hum | Q8TDU7_Hum | EDG4_Hum |
FMLR_Hum | Q8TDE0_Hum | NY1R_Hum | CKR5_Hum | CKR7_Hum | OPS5_Dro | GP43_Hum | Q96JZ8_Hum | GP12_Hum |
GP32_Hum | Q96LB1_Hum | NY2R_Hum | CKR8_Hum | CKRA_Hum | OPS6_Dro | GP82_Hum | Â | GPR3_Hum |
GP44_Hum | Â | NY4R_Hum | CXC1_Hum | CKRB_Hum | OPSB_Hum | HM74_Hum | Â | GPR6_Hum |
GPR1_Hum | Â | NY5R_Hum | O75307_Hum | CML2_Hum | OPSD_Hum | P2Y2_Hum | Â | MC3R_Hum |
L4R1_Hum | Â | NYR_Dro | Â | DUFF_Hum | OPSG_Hum | P2Y4_Hum | Â | MC4R_Hum |
L4R2_Hum | Â | PKR1_Hum | Â | IL8A_Hum | OPSX_Hum | P2Y6_Hum | Â | MC5R_Hum |
Q8NGA4_Hum | Â | PKR2_Hum | Â | IL8B_Hum | Q96FC5_Hum | P2YB_Hum | Â | O95136_Hum |
Q8TDT2_Hum | Â | Q8SZ35_Dro | Â | CKR9_Hum | Q9VTU7_Dro | P2YR_Hum | Â | O95977_Hum |
| Â | Â | NY6R_Hum | Â | Q96CH1_Hum | Â | Q8TDQ8_Hum | Â | Q8WUL7_Hum |
| Â | Â | Q9VRM0_Dro | Â | RDC1_Hum | Â | Q8TDS5_Hum | Â | Q9H228_Hum |
| Â | Â | Q9VW75_Dro | Â | Â | Â | Q96P68_Hum | Â | Q9NRB8_Hum |
| Â | Â | Q9W189_Dro | Â | Â | Â | Q9BXC0_Hum | Â | Q9NYN8_Hum |
| Â | Â | TLR1_Dro | Â | Â | Â | Â | Â | Â |
| Â | Â | TLR2_Dro | Â | Â | Â | Â | Â | Â |
CLUSTER 18 | CLUSTER 19 | CLUSTER 20 | CLUSTER 21 | CLUSTER 22 | CLUSTER 23 | CLUSTER 24 | ||
O00325_Hum | EBI2_Hum | 5H4_Hum | ML1A_Hum | 5H1A_Hum | AA1R_Hum | GP63_Hum | 5H2A_Hum | HH2R_Hum |
O75228_Hum | FK79_Hum | O14804_Hum | ML1B_Hum | 5H1B_Hum | AA2A_Hum | GP85_Hum | 5H2B_Hum | O61730_Dro |
PD2R_Hum | GP18_Hum | Q969N4_Hum | ML1X_Hum | 5H1D_Hum | AA2B_Hum | HH1R_Hum | 5H2C_Hum | O97171_Dro |
PE21_Hum | GP20_Hum | Q96RI8_Hum | O77269_Dro | 5H1E_Hum | AA3R_Hum | HH3R_Hum | 5H6_Hum | OAR_Dro |
PE22_Hum | GP35_Hum | Q96RI9_Hum | O77270_Dro | 5H1F_Hum | ACM1_Dro | HH4R_Hum | A1AB_Hum | Q13675_Hum |
PE24_Hum | GP68_Hum | Q96RJ0_Hum | Q9NQS5_Hum | 5H5A_Hum | ACM1_Hum | O43898_Hum | A1AD_Hum | Q8IPN2_Dro |
PF2R_Hum | GPR4_Hum | Q9P1P4_Hum | Â | 5H7_Hum | ACM2_Hum | Q8NDV2_Hum | A2AA_Hum | Q8IS45_Dro |
PI2R_Hum | O75819_Hum | Q9P1P5_Hum | Â | 5HT1_Dro | ACM3_Hum | Q8TDV4_Hum | A2AB_Hum | Q8N6U8_Hum |
Q9VVJ1_Dro | P2Y5_Hum | Q9VCZ3_Dro | Â | 5HTA_Dro | ACM4_Hum | Q9VAA2_Dro | A2AC_Hum | Q8NGU3_Hum |
| Â | P2Y9_Hum | Q9VG54_Dro | Â | 5HTB_Dro | ACM5_Hum | Q9VHW1_Dro | B1AR_Hum | Q8TDV5_Hum |
| Â | P2YA_Hum | Â | Â | Q16538_Hum | GP21_Hum | Q9VMI4_Dro | B2AR_Hum | Q96P66_Hum |
| Â | PAR1_Hum | Â | Â | Q8TDV2_Hum | GP27_Hum | SRB3_Hum | B3AR_Hum | Q9GZN0_Hum |
| Â | PAR2_Hum | Â | Â | Q9VEG1_Dro | GP52_Hum | Â | D3DR_Hum | Q9NZR3_Hum |
| Â | PAR3_Hum | Â | Â | Q9VEG2_Dro | GP62_Hum | Â | D4DR_Hum | Q9VBG4_Dro |
| Â | PAR4_Hum | Â | Â | Â | Â | Â | DADR_Hum | Q9VE32_Dro |
| Â | Q8N580_Hum | Â | Â | Â | Â | Â | DBDR_Hum | Q9VHP6_Dro |
| Â | Q9H1C0_Hum | Â | Â | Â | Â | Â | DOP1_Dro | Q9W3V5_Dro |
| Â | Q9UNW8_Hum | Â | Â | Â | Â | Â | DOP2_Dro | Â |
CLUSTER 25 | CLUSTER 26 | CLUSTER 27 | CLUSTER 28 | CLUSTER 29 | CLUSTER 30 | CLUSTER 31 | CLUSTER 32 | |
CALR_Hum | MTH_Dro | BAI1_Hum | Q8NG96_Hum | MGR_Dro | CASR_Hum | O75205_Hum | GBR1_Hum | FRIZ_Dro |
CGRR_Hum | MTH1_Dro | BAI3_Hum | Q8NGA7_Hum | MGR1_Hum | Q8NGV9_Hum | O95357_Hum | GBR2_Hum | FRZ2_Dro |
CRF2_Hum | MTH2_Dro | CD97_Hum | Q8NGB3_Hum | MGR2_Hum | Q8NGW9_Hum | Q9NQ84_Hum | Q8NFN8_Hum | FRZ3_Dro |
GIPR_Hum | MTH3_Dro | CLR1_Hum | Q8NGW8_Hum | MGR3_Hum | Q8NGZ7_Hum | Q9NZD1_Hum | Q9BML5_Dro | FRZ4_Dro |
GLP1_Hum | MTH4_Dro | CLR2_Hum | Q8NH12_Hum | MGR4_Hum | Q8NHZ9_Hum | BOSS_Dro | Q9BML7_Dro | FZ10_Hum |
GLP2_Hum | MTH5_Dro | CLR3_Hum | Q8SZ78_Dro | MGR5_Hum | Â | Â | Q9V3Q9_Dro | FZD1_Hum |
GLR_Hum | MTH6_Dro | O94910_Hum | Q8T4B2_Dro | MGR6_Hum | Â | Â | Q9VKA4_Dro | FZD2_Hum |
GRFR_Hum | MTH7_Dro | O95490_Hum | Q8WXG9_Hum | MGR8_Hum | Â | Â | Q9VNZ5_Dro | FZD3_Hum |
PACR_Hum | MTH8_Dro | Q8IXE3_Hum | Q96JW0_Hum | Q8NFS4_Hum | Â | Â | Q9VR40_Dro | FZD4_Hum |
PTR2_Hum | MTH9_Dro | Q8IZF1_Hum | Q96K78_Hum | Q9V4U4_Dro | Â | Â | Q9Y133_Dro | FZD5_Hum |
PTRR_Hum | MTHA_Dro | Q8IZF2_Hum | Q96PE1_Hum | Â | Â | Â | Â | FZD6_Hum |
Q8NG71_Hum | MTHC_Dro | Q8IZF3_Hum | Q9BY15_Hum | Â | Â | Â | Â | FZD7_Hum |
Q8NHB4_Hum | Q8INM0_Dro | Q8IZF4_Hum | Q9HAR2_Hum | Â | Â | Â | Â | FZD8_Hum |
Q9V6C7_Dro | Q8IPD0_Dro | Q8IZF5_Hum | Q9HBW9_Hum | Â | Â | Â | Â | FZD9_Hum |
Q9V6N4_Dro | Â | Q8IZF6_Hum | Q9V4V8_Dro | Â | Â | Â | Â | SMO_Dro |
Q9V716_Dro | Â | Q8IZF7_Hum | STAN_Dro | Â | Â | Â | Â | SMO_Hum |
SCRC_Hum | Â | Q8IZP9_Hum | Â | Â | Â | Â | Â | Â |
VIPR_Hum | Â | Â | Â | Â | Â | Â | Â | Â |
VIPS_Hum | Â | Â | Â | Â | Â | Â | Â | Â |