Figure 3

Ribbon representation of the core structure of the FBG domain of tachylectin 5A (PDB: 1JC9) and recombinant human γ-fibrinogen carboxyl terminal fragment (PDB: 2FIB). A. Ribbon plot of the FBG domain of TL5A. The domain shown here is a cartoon representation from the crystal structure. Main α-helices and β-sheets were shown in the figure. The residues forming the ligand-binding packet are depicted in the stick format and labeled in red. B. Superposition of the crystal structure of the FBG domain of TL5A (grey) and human γ-fibrinogen carboxyl terminal fragment (golden). By aligning TL5A and the γ chain fragment, the region composed of 178aa residues at the C-terminal regions of both proteins was used to generate superposition ribbon plot. Loop P-1 and P-3 in fibrinogen γ chain fragment are represented in green.