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Table 4 Highly occuring COGs with pI varying across both the acidic and basic clusters. Table headers are the same as in Table 2.

From: Comparison of theoretical proteomes: Identification of COGs with conserved and variable pI within the multimodal pI distribution

COG P(a) P(b) P(v) F Role Hbs Eco Hpy Buc
COG0760 0.29 0.31 0.60 O Parvulin-like peptidyl-prolyl isomerase - 6.83 9.04 9.65
COG0725 0.31 0.29 0.60 P ABC-type molybdate transport system, periplasmic component 4.90 7.53 9.70 -
COG0042 0.44 0.25 0.60 R Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family 4.82 6.04 9.20 -
COG0275 0.28 0.46 0.60 M Predicted S-adenosylmethionine-dependent methyltransferase - 5.92 8.99 9.93
COG0258 0.69 0.30 0.61 L 5'-3' exonuclease (including N-terminal domain of PolI) 4.06 5.74 9.06 9.59
COG0640 0.38 0.28 0.61 K Predicted transcriptional regulators 4.49 8.48 - -
COG0444 0.37 0.27 0.61 E ABC-type dipeptide/oligopeptide/nickel transport system, ATPase componen 4.36 6.64 8.29 -
COG0009 0.61 0.30 0.61 J Putative translation factor (SUA5) 4.43 5.36 - 9.52
COG0226 0.39 0.30 0.62 P ABC-type phosphate transport system, periplasmic component 4.04 8.37 - -
COG1475 0.41 0.26 0.62 K Predicted transcriptional regulators 4.46 6.78 8.39 -
COG0190 0.51 0.30 0.62 H 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase 4.36 5.61 8.74 9.70
COG1057 0.31 0.33 0.62 H Nicotinic acid mononucleotide adenylyltransferase - 5.38 8.80 9.68
COG0482 0.42 0.28 0.62 J Predicted tRNA methyltransferase, contains the PP-loop ATPase domain - 4.89 8.82 9.50
COG1121 0.29 0.35 0.62 P ABC-type Mn/Zn transport systems, ATPase component 4.61 9.44 - 9.21
COG0359 0.31 0.48 0.62 J Ribosomal protein L9 - 5.82 8.80 10.29
COG0858 0.46 0.29 0.62 J Ribosome-binding factor A - 5.58 7.55 9.88
COG0356 0.30 0.25 0.62 C F0F1-type ATP synthase a subunit - 6.18 6.34 7.64
COG0501 0.29 0.41 0.63 O Zn-dependent protease with chaperone function 7.18 7.10 7.86 6.91
COG0350 0.31 0.46 0.64 L Methylated DNA-protein cysteine methyltransferase 5.67 7.13 9.38 -
COG1136 0.53 0.29 0.64 R ABC-type transport systems, involved in lipoprotein release, ATPase components 6.85 6.66 9.03 7.53
COG0816 0.26 0.36 0.64 L Predicted endonuclease involved in recombination - 6.21 9.05 9.81
COG1159 0.36 0.26 0.64 R GTPases - 6.54 8.86 9.78
COG0712 0.31 0.29 0.65 C F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein) - 4.92 7.56 9.83
COG1160 0.33 0.46 0.65 R Predicted GTPases - 5.62 9.15 9.92
COG0463 0.31 0.55 0.66 M Glycosyltransferases involved in cell wall biogenesis 4.80 8.55 8.87 -
COG0324 0.34 0.30 0.66 J tRNA delta(2)-isopentenylpyrophosphate transferase - 5.58 9.56 9.58
COG0617 0.32 0.36 0.66 J tRNA nucleotidyltransferase/poly(A) polymerase - 7.84 9.14 9.35
COG1385 0.35 0.32 0.67 S Uncharacterized BCR - 6.80 9.08 9.71
COG1825 0.34 0.34 0.67 J Ribosomal protein L25 (general stress protein Ctc) - 9.60 9.41 9.91
COG0358 0.63 0.30 0.67 L DNA primase (bacterial type) 4.35 5.62 8.97 9.48
COG0593 0.42 0.32 0.69 L ATPase involved in DNA replication initiation - 6.97 8.35 9.55
COG0052 0.64 0.33 0.69 J Ribosomal protein S2 4.06 6.38 6.82 9.61
COG0616 0.49 0.32 0.69 N Periplasmic serine proteases (ClpP class) 4.93 7.44 9.41 9.66
COG0212 0.39 0.35 0.70 H 5-formyltetrahydrofolate cyclo-ligase 4.42 6.10 9.98 -
COG0470 0.59 0.34 0.70 L ATPase involved in DNA replication 4.47 6.46 8.70 9.39
COG1132 0.33 0.44 0.70 Q ABC-type multidrug/protein/lipid transport system, ATPase component 4.43 6.91 9.23 9.60
COG0750 0.33 0.52 0.71 M Predicted membrane-associated Zn-dependent proteases 1 4.91 6.41 9.18 -
COG0341 0.36 0.40 0.71 N Preprotein translocase subunit SecF 4.53 5.46 8.73 -
COG0475 0.35 0.32 0.71 P Kef-type K+ transport systems, membrane components - 5.13 9.12 -
COG0566 0.43 0.35 0.72 J rRNA methylases - 7.15 9.18 -
COG0438 0.35 0.46 0.73 M Predicted glycosyltransferases 4.96 8.21 8.66 -
COG0223 0.43 0.36 0.73 J Methionyl-tRNA formyltransferase - 6.01 8.87 9.80
COG0237 0.60 0.36 0.74 H Dephospho-CoA kinase 1 4.59 5.64 8.91 10.26
COG0668 0.36 0.42 0.76 M Small-conductance mechanosensitive channel 5.29 7.56 8.87 9.50
COG0532 0.57 0.34 0.77 J Translation initiation factor 2 (GTPase) 4.33 5.76 6.93 9.38
COG0484 0.35 0.41 0.82 O Molecular chaperones (contain C-terminal Zn finger domain) 4.54 7.94 8.12 9.17
COG0164 0.39 0.44 0.83 L Ribonuclease H 4.41 6.91 8.95 -
COG0020 0.38 0.47 0.85 I Undecaprenyl pyrophosphate synthase 5.11 6.29 8.97 9.45
COG0681 0.41 0.49 0.86 N Signal peptidase 4.99 6.46 8.34 9.51
COG0244 0.40 0.53 0.87 J Ribosomal protein L10 3.80 9.04 9.36 9.98
COG0130 0.45 0.43 0.88 J Pseudouridine synthase 5.37 5.59 - 9.74
      Mean 4.76 6.64 8.75 9.47
      Standard Deviation 0.7 1.14 0.73 0.69