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Table 4 Highly occuring COGs with pI varying across both the acidic and basic clusters. Table headers are the same as in Table 2.

From: Comparison of theoretical proteomes: Identification of COGs with conserved and variable pI within the multimodal pI distribution

COG

P(a)

P(b)

P(v)

F

Role

Hbs

Eco

Hpy

Buc

COG0760

0.29

0.31

0.60

O

Parvulin-like peptidyl-prolyl isomerase

-

6.83

9.04

9.65

COG0725

0.31

0.29

0.60

P

ABC-type molybdate transport system, periplasmic component

4.90

7.53

9.70

-

COG0042

0.44

0.25

0.60

R

Predicted TIM-barrel enzymes, possibly dehydrogenases, nifR3 family

4.82

6.04

9.20

-

COG0275

0.28

0.46

0.60

M

Predicted S-adenosylmethionine-dependent methyltransferase

-

5.92

8.99

9.93

COG0258

0.69

0.30

0.61

L

5'-3' exonuclease (including N-terminal domain of PolI)

4.06

5.74

9.06

9.59

COG0640

0.38

0.28

0.61

K

Predicted transcriptional regulators

4.49

8.48

-

-

COG0444

0.37

0.27

0.61

E

ABC-type dipeptide/oligopeptide/nickel transport system, ATPase componen

4.36

6.64

8.29

-

COG0009

0.61

0.30

0.61

J

Putative translation factor (SUA5)

4.43

5.36

-

9.52

COG0226

0.39

0.30

0.62

P

ABC-type phosphate transport system, periplasmic component

4.04

8.37

-

-

COG1475

0.41

0.26

0.62

K

Predicted transcriptional regulators

4.46

6.78

8.39

-

COG0190

0.51

0.30

0.62

H

5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

4.36

5.61

8.74

9.70

COG1057

0.31

0.33

0.62

H

Nicotinic acid mononucleotide adenylyltransferase

-

5.38

8.80

9.68

COG0482

0.42

0.28

0.62

J

Predicted tRNA methyltransferase, contains the PP-loop ATPase domain

-

4.89

8.82

9.50

COG1121

0.29

0.35

0.62

P

ABC-type Mn/Zn transport systems, ATPase component

4.61

9.44

-

9.21

COG0359

0.31

0.48

0.62

J

Ribosomal protein L9

-

5.82

8.80

10.29

COG0858

0.46

0.29

0.62

J

Ribosome-binding factor A

-

5.58

7.55

9.88

COG0356

0.30

0.25

0.62

C

F0F1-type ATP synthase a subunit

-

6.18

6.34

7.64

COG0501

0.29

0.41

0.63

O

Zn-dependent protease with chaperone function

7.18

7.10

7.86

6.91

COG0350

0.31

0.46

0.64

L

Methylated DNA-protein cysteine methyltransferase

5.67

7.13

9.38

-

COG1136

0.53

0.29

0.64

R

ABC-type transport systems, involved in lipoprotein release, ATPase components

6.85

6.66

9.03

7.53

COG0816

0.26

0.36

0.64

L

Predicted endonuclease involved in recombination

-

6.21

9.05

9.81

COG1159

0.36

0.26

0.64

R

GTPases

-

6.54

8.86

9.78

COG0712

0.31

0.29

0.65

C

F0F1-type ATP synthase delta subunit (mitochondrial oligomycin sensitivity protein)

-

4.92

7.56

9.83

COG1160

0.33

0.46

0.65

R

Predicted GTPases

-

5.62

9.15

9.92

COG0463

0.31

0.55

0.66

M

Glycosyltransferases involved in cell wall biogenesis

4.80

8.55

8.87

-

COG0324

0.34

0.30

0.66

J

tRNA delta(2)-isopentenylpyrophosphate transferase

-

5.58

9.56

9.58

COG0617

0.32

0.36

0.66

J

tRNA nucleotidyltransferase/poly(A) polymerase

-

7.84

9.14

9.35

COG1385

0.35

0.32

0.67

S

Uncharacterized BCR

-

6.80

9.08

9.71

COG1825

0.34

0.34

0.67

J

Ribosomal protein L25 (general stress protein Ctc)

-

9.60

9.41

9.91

COG0358

0.63

0.30

0.67

L

DNA primase (bacterial type)

4.35

5.62

8.97

9.48

COG0593

0.42

0.32

0.69

L

ATPase involved in DNA replication initiation

-

6.97

8.35

9.55

COG0052

0.64

0.33

0.69

J

Ribosomal protein S2

4.06

6.38

6.82

9.61

COG0616

0.49

0.32

0.69

N

Periplasmic serine proteases (ClpP class)

4.93

7.44

9.41

9.66

COG0212

0.39

0.35

0.70

H

5-formyltetrahydrofolate cyclo-ligase

4.42

6.10

9.98

-

COG0470

0.59

0.34

0.70

L

ATPase involved in DNA replication

4.47

6.46

8.70

9.39

COG1132

0.33

0.44

0.70

Q

ABC-type multidrug/protein/lipid transport system, ATPase component

4.43

6.91

9.23

9.60

COG0750

0.33

0.52

0.71

M

Predicted membrane-associated Zn-dependent proteases 1

4.91

6.41

9.18

-

COG0341

0.36

0.40

0.71

N

Preprotein translocase subunit SecF

4.53

5.46

8.73

-

COG0475

0.35

0.32

0.71

P

Kef-type K+ transport systems, membrane components

-

5.13

9.12

-

COG0566

0.43

0.35

0.72

J

rRNA methylases

-

7.15

9.18

-

COG0438

0.35

0.46

0.73

M

Predicted glycosyltransferases

4.96

8.21

8.66

-

COG0223

0.43

0.36

0.73

J

Methionyl-tRNA formyltransferase

-

6.01

8.87

9.80

COG0237

0.60

0.36

0.74

H

Dephospho-CoA kinase 1

4.59

5.64

8.91

10.26

COG0668

0.36

0.42

0.76

M

Small-conductance mechanosensitive channel

5.29

7.56

8.87

9.50

COG0532

0.57

0.34

0.77

J

Translation initiation factor 2 (GTPase)

4.33

5.76

6.93

9.38

COG0484

0.35

0.41

0.82

O

Molecular chaperones (contain C-terminal Zn finger domain)

4.54

7.94

8.12

9.17

COG0164

0.39

0.44

0.83

L

Ribonuclease H

4.41

6.91

8.95

-

COG0020

0.38

0.47

0.85

I

Undecaprenyl pyrophosphate synthase

5.11

6.29

8.97

9.45

COG0681

0.41

0.49

0.86

N

Signal peptidase

4.99

6.46

8.34

9.51

COG0244

0.40

0.53

0.87

J

Ribosomal protein L10

3.80

9.04

9.36

9.98

COG0130

0.45

0.43

0.88

J

Pseudouridine synthase

5.37

5.59

-

9.74

     

Mean

4.76

6.64

8.75

9.47

     

Standard Deviation

0.7

1.14

0.73

0.69

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