Figure 1

Dot plot representation [63] of a 0.74 Mb region of human chromosome 1 (bases 1276000–1350000) annotated (below) according to the locations of PRAME genes (blue arrowheads) and pseudogenes (red arrowheads), approximately to scale. Gene or pseudogene orientation is indicated by arrowhead direction. PRAME gene or pseudogene numbers are provided beneath the arrowheads. Single short diagonals represent alignments of two PRAME genes or pseudogenes. Gaps in the assembly (bases 13015219–13065218 and 13302469–13352468) are indicated, on the axes, by thick black bars. Two recent segmental duplications (Homo_7–12 and 15–20, and Homo_19–25 and 26–32; see text) are highlighted in blue and pink, respectively. Regions identified by Sebat et al. [12] or by Iafrate et al. [36], as being copy number polymorphic are indicated by a yellow, or a black-and-yellow-striped, bar, respectively.