Similarity of T. cruzi ePKs to those in the 4-kinome dataset. Full-length proteins were tested by BLAST analysis against the database of catalytic domains of all human, Saccharomyces cerevisiae, Drosophila melanogaster, and Caenorhabditis elegans protein kinases. The best E-value is graphed for each kinase, which are clustered according to their classification group. Non-cat: protein kinases predicted to be non-catalytic due to lack of subdomain I or catalytic residues. Different colors were used to facilitate viewing of closely spaced spots.