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Table 1 The number of genes that obey the rules of mitochondrial pyrimidine-purine base composition. All oxidative phosphorylation complex protein genes were included as membrane protein genes. Soluble mitochondrial protein genes included those of ribosomal proteins, maturases and endonucleases from intronic ORFs, and polymerase-like proteins. Unknown ORFs, hypothetical proteins, and proteins of unknown localization were excluded from the analysis. Transcripts that do not follow Rule #1 include almost all Dictyostelium transcripts, Chondrus crispus SDH2, Porphyra purpurea SDH2, COX2, and ymf39, Marchantia polymorpha NAD7 and ATPa, and Arabidopsis NAD7, NAD9, and ATP1. The Chlamydomonas reinhardtii rtl transcript breaks Rule #3.

From: Mitochondrial-encoded membrane protein transcripts are pyrimidine-rich while soluble protein transcripts and ribosomal RNA are purine-rich

  Organism Name Rule 1 Rule 2 Rule 3 Hypothetical Proteins or Unknown Localization
Genbank Accession Latin Common Holds (Fails) Holds (Fails) Holds (Fails)  
[NC_001807] Homo sapiens Human 12 (1) 2 - -
[NC_005089] Mus musculus Mouse 12 (1) 2 - -
[NC_001913] Oryctolagus cuniculus Rabbit 12 (1) 2 - -
[NC_002008] Canis familiaris Dog 13 2 - -
[NC_000845] Sus scrofa Pig 13 2 - -
[NC_001323] Gallus gallus Chicken 13 2 - -
[NC_002784] Dromaius novaehollandiae Emu 13 2 - -
[NC_001573] Xenopus laevis Frog 13 2 - -
[NC_002333] Danio rerio Zebrafish 13 2 - -
[NC_001709] Drosophila melanogaster Fruit fly 13 2 - -
[NC_002074] Rhipicephalus sanguineus Brown dog tick 13 2 - -
[NC_003344] Thyropygus sp. DVL-2001 Giant millipede 13 2 - -
[NC_001453] Strongylocentrot. purpuratus Sea urchin 13 2 - -
[NC_000933] Metridium senile Brown sea anemone 13 2 1 -
[NC_001328] Caenorhabditis elegans Soil nematode 12 1 (1) - -
[NC_001224] Saccharomyces cerevisiae Baker's yeast 7 3 11 1
[NC_001326] Schizosaccharomyces pombe Fission yeast 6 2 - 4
[NC_000895] Dictyostelium discoideum Slime mold 2(13) 2 14 11
[NC_001677] Chondrus crispus Irish moss/Red algae 18(1) 2 (1) 5 1
[NC_002007] Porphyra purpurea Seaweed/Red algae 16(3) 2 6 6
[NC_001638] Chlamydomonas reinhardtii Green algae 7 11(3) 0(1) -
[NC_000892] Pedinomonas minor Green algae 11 3 - -
[NC_001660] Marchantia polymorpha Liverwort 13(2) 3 17 43
[NC_001284] Arabidopsis thaliana Thale cress 19(3) 2 (1) 8 87