Figure 7
From: A TNF-induced gene expression program under oscillatory NF-κB control
Phylogenetic analysis of NF-κB dependent promoters. (a) Early gene promoters. Promoters spanning from -1000 bp to the first nontranslated exon were aligned between human and mouse genes. Shown are the VISA identity curves [49]. For each curve, the percent sequence conservation is plotted over a sliding 20 base pair window (from 0–100% identity). Shaded regions indicated significant regions of sequence conservation. The location of NF-κB-binding sites within these conserved domains are displayed at top (location indicated by I). The presence of AP-1 sites is indicated by green asterix (*). (b) Late gene promoters. For each late gene promoter indicated, analysis as in 7a.