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Table 3 Fold change of repressed gene expression in B lymphoblasts treated with ionophore A23187. Genes listed here showed a decreased gene expression (2-fold or more) in at least one of the three B lymphoblasts cultured for 48 h with 200 nM A23187. Data are fold changes calculated from hybridization values in treated versus non treated cells for each one of the B lymphoblasts respectively (see fold-changes < 0.5 in additional file 1 corresponding to <-1/0.5 in this table). For each functional group, the genes were ordered by using a program for gene clustering. *Fourteen genes are basally under-expressed in Scott B lymphoblasts compared to control cells.

From: Identification of genes involved in Ca2+ ionophore A23187-mediated apoptosis and demonstration of a high susceptibility for transcriptional repression of cell cycle genes in B lymphoblasts from a patient with Scott syndrome

Accession no. control daughter's Scott Gene definition
     Histones
X57129 -3.79 -3.59 -6.54 H1.2*
X00088 -6.80 -3.41 -3.62 H2b/r*
Z80779 -4.49 -2.11 -2.31 H2B/g*
Z80782 -2.96 -2.42 -3.41 H2B/k*
Z83336 -2.98 -2.12 -2.08 H2B/d*
L19779 -2.97 -2.01 -1.66 H2A.2*
AJ223352 -2.57 -1.71 -2.57 H2B/a*
Z83740 -2.92 -1.69 -1.83 H2B/c*
U91328 -2.81 -1.31 -1.65 H2A-like protein*
AJ223353 -3.12 -1.92 -1.27 H2B/b
Z83738 -3.08 -1.88 -1.98 H2B/e*
Z80780 -3.06 -1.84 -2.85 H2B/h*
X14850 -1.45 -1.40 -3.20 H2A.X
     Cell cycle and proliferation
AF041248 -2.58 -1.78 -1.84 CDKN2C*
X04757 -2.53 -2.55 -1.31 alpha-tubulin
J00139 -2.35 -2.35 -5.23 dihydrofolate reductase
U05340 -3.12 -2.44 -6.60 p55CDC
U37426 -2.07 -1.41 -5.10 HKSP
AF067656 -2.18 -1.26 -4.08 ZW10 interactor
AF011468 -2.20 -1.97 -6.05 BTAK
M25753 -2.13 -1.91 -7.30 cyclin B
Z36714 -2.20 -1.94 -3.74 cyclin F
D55716 -2.04 -1.57 -3.25 P1cdc47
D14678 -1.92 -2.05 -3.63 kinesin-related protein
X76771 -1.85 -1.17 -2.75 flap endonuclease-1
X62534 -1.38 -1.15 -3.20 HMG-2
X54942 -1.43 -1.48 -2.79 ckshs2
L37747 -1.65 -1.63 -2.84 lamin B1
L25876 -1.91 -1.69 -3.63 CIP2
D14657 -1.82 -1.27 -3.35 mRNA for KIAA0101 (p15-PAF)
L16991 -1.92 -1.78 -4.08 CDC8
AB024704 -1.76 -1.86 -4.60 fls353
X13293 -1.93 -1.69 -5.74 B-myb*
X05360 -1.84 -1.04 -4.12 CDC2
X51688 -1.62 1.05 -5.23 cyclin A
U63743 -2.00 -1.96 -6.59 centromere-associated kinesin
AF017790 -1.85 -1.55 -4.40 retinoblastoma-associated protein
AF004022 -1.92 -1.62 -5.11 protein kinase STK12
U14518 -2.00 -1.65 -5.02 CENP-A
U30872 -1.68 -1.49 -5.00 mitosin
J04088 -1.70 -1.22 -5.16 top2
AF035933 -1.80 -1.21 -4.54 protein kinase SSK1
K02581 -1.91 -1.63 -5.02 thymidine kinase*
U73379 -1.79 -1.66 -8.96 cyclin-selective ubiquitin carrier
     Micellaneous
U49184 -11.24 -6.64 -4.10 occludin
L02950 -5.26 -4.49 -3.85 mu-crystallin
AB047079 -2.20 -2.54 -4.21 IRE1b
U29343 -2.11 -1.58 -4.07 hyaluronan receptor
D13633 -2.21 -1.72 -6.35 putative gene KIAA0008
AF057557 -1.75 -3.43 -3.45 TOSO
X59350 -1.95 -1.06 -3.43 CD22
AF053641 -1.46 -1.45 -2.65 CSE1
AF274943 -1.20 -1.06 -2.45 PNAS-18
M91438 -1.18 -1.02 -3.41 HUSI-II