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Table 3 Fold change of repressed gene expression in B lymphoblasts treated with ionophore A23187. Genes listed here showed a decreased gene expression (2-fold or more) in at least one of the three B lymphoblasts cultured for 48 h with 200 nM A23187. Data are fold changes calculated from hybridization values in treated versus non treated cells for each one of the B lymphoblasts respectively (see fold-changes < 0.5 in additional file 1 corresponding to <-1/0.5 in this table). For each functional group, the genes were ordered by using a program for gene clustering. *Fourteen genes are basally under-expressed in Scott B lymphoblasts compared to control cells.

From: Identification of genes involved in Ca2+ ionophore A23187-mediated apoptosis and demonstration of a high susceptibility for transcriptional repression of cell cycle genes in B lymphoblasts from a patient with Scott syndrome

Accession no.

control

daughter's

Scott

Gene definition

    

Histones

X57129

-3.79

-3.59

-6.54

H1.2*

X00088

-6.80

-3.41

-3.62

H2b/r*

Z80779

-4.49

-2.11

-2.31

H2B/g*

Z80782

-2.96

-2.42

-3.41

H2B/k*

Z83336

-2.98

-2.12

-2.08

H2B/d*

L19779

-2.97

-2.01

-1.66

H2A.2*

AJ223352

-2.57

-1.71

-2.57

H2B/a*

Z83740

-2.92

-1.69

-1.83

H2B/c*

U91328

-2.81

-1.31

-1.65

H2A-like protein*

AJ223353

-3.12

-1.92

-1.27

H2B/b

Z83738

-3.08

-1.88

-1.98

H2B/e*

Z80780

-3.06

-1.84

-2.85

H2B/h*

X14850

-1.45

-1.40

-3.20

H2A.X

    

Cell cycle and proliferation

AF041248

-2.58

-1.78

-1.84

CDKN2C*

X04757

-2.53

-2.55

-1.31

alpha-tubulin

J00139

-2.35

-2.35

-5.23

dihydrofolate reductase

U05340

-3.12

-2.44

-6.60

p55CDC

U37426

-2.07

-1.41

-5.10

HKSP

AF067656

-2.18

-1.26

-4.08

ZW10 interactor

AF011468

-2.20

-1.97

-6.05

BTAK

M25753

-2.13

-1.91

-7.30

cyclin B

Z36714

-2.20

-1.94

-3.74

cyclin F

D55716

-2.04

-1.57

-3.25

P1cdc47

D14678

-1.92

-2.05

-3.63

kinesin-related protein

X76771

-1.85

-1.17

-2.75

flap endonuclease-1

X62534

-1.38

-1.15

-3.20

HMG-2

X54942

-1.43

-1.48

-2.79

ckshs2

L37747

-1.65

-1.63

-2.84

lamin B1

L25876

-1.91

-1.69

-3.63

CIP2

D14657

-1.82

-1.27

-3.35

mRNA for KIAA0101 (p15-PAF)

L16991

-1.92

-1.78

-4.08

CDC8

AB024704

-1.76

-1.86

-4.60

fls353

X13293

-1.93

-1.69

-5.74

B-myb*

X05360

-1.84

-1.04

-4.12

CDC2

X51688

-1.62

1.05

-5.23

cyclin A

U63743

-2.00

-1.96

-6.59

centromere-associated kinesin

AF017790

-1.85

-1.55

-4.40

retinoblastoma-associated protein

AF004022

-1.92

-1.62

-5.11

protein kinase STK12

U14518

-2.00

-1.65

-5.02

CENP-A

U30872

-1.68

-1.49

-5.00

mitosin

J04088

-1.70

-1.22

-5.16

top2

AF035933

-1.80

-1.21

-4.54

protein kinase SSK1

K02581

-1.91

-1.63

-5.02

thymidine kinase*

U73379

-1.79

-1.66

-8.96

cyclin-selective ubiquitin carrier

    

Micellaneous

U49184

-11.24

-6.64

-4.10

occludin

L02950

-5.26

-4.49

-3.85

mu-crystallin

AB047079

-2.20

-2.54

-4.21

IRE1b

U29343

-2.11

-1.58

-4.07

hyaluronan receptor

D13633

-2.21

-1.72

-6.35

putative gene KIAA0008

AF057557

-1.75

-3.43

-3.45

TOSO

X59350

-1.95

-1.06

-3.43

CD22

AF053641

-1.46

-1.45

-2.65

CSE1

AF274943

-1.20

-1.06

-2.45

PNAS-18

M91438

-1.18

-1.02

-3.41

HUSI-II