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Table 1 NO•-regulated cell cycle related genes

From: cGMP-independent nitric oxide signaling and regulation of the cell cycle

GenBank

Symbol

Functional category

Fold changea

G1/S

J04111

JUN

Regulation of cell cycle

3.68 ± 0.76

U09579

CDKN1A (p21)

CDK inhibitor

2.06 ± 0.58

U77949

CDC6

DNA replication

1.95 ± 0.48

M74093

CCNE1

Cell cycle control

1.77 ± 0.31

X89398

UNG

DNA repair

1.68 ± 0.30

S49592

E2F1

G1 phase of mitotic cell cycle

1.60 ± 0.19

X61123

BTG1

Negative regulation of cell proliferation

1.60 ± 0.28

L13689

BMI1

Modifies chromatin

0.67 ± 0.09

U67369

GFI1

G1/S-specific transcription in mitotic cell cycle

0.54 ± 0.06

U22376

c-Myb

Cell cycle control

0.30 ± 0.10

G2

U66838

CCNA1

Regulation of CDK activity

0.60 ± 0.12

Z36714

CCNF

Regulation of cell cycle

0.60 ± 0.11

J04088

  

0.57 ± 0.14

L47276

TOP2A b

Spindle assembly, chromsome condensation

0.42 ± 0.07

X05360

CDC2

Start control point of mitotic cell cycle

0.57 ± 0.11

U28386

KPNA2

Cytoskeleton organization and biogenesis

0.51 ± 0.05

D14678

KIFC1

Spindle assembly, chromsome condensation

0.44 ± 0.10

U14518

CENPA

Chromosome organization and biogenesis

0.38 ± 0.06

G2/M

U48807

DUSP4

Regulation of cell cycle

1.40 ± 0.35

U63743

KIF2C

Microtubule motor activity

0.72 ± 0.10

U83115

AIM1

Tumor supressor, cytoskeleton

0.71 ± 0.07

M34458

LMNB1

Cytoskeletal anchoring

0.66 ± 0.16

D63880

CNAP1

Mitotic surveilance

0.63 ± 0.05

X65550

MKI67

Chromatin/chromosome structure

0.61 ± 0.09

S78187

CDC25B

Cell cycle control

0.60 ± 0.05

D38553

BRRN1

Chromatid separation

0.59 ± 0.08

U73379

UBE2C

Protein degradation

0.54 ± 0.08

U30872

CENPF

Mitosis

0.53 ± 0.07

Z15005

CENPE

Mitotic chromosome movement

0.53 ± 0.10

U29343

HMMR

Mitotic surveilance, cell motility

0.51 ± 0.11

U05340

CDC20

Ubiquitin-dependent protein degradation

0.49 ± 0.07

M86699

TTK

Spindle assembly/mitotic checkpoint

0.47 ± 0.05

U01038

PLK

Mitosis

0.44 ± 0.04

M25753

CCNB1

Mitotic checkpoint

0.43 ± 0.07

D38751

KIF22

Mitosis

0.40 ± 0.18

U04810

TROAP

Cell adhesion

0.24 ± 0.03

  1. a Fold change comparing glutathione (GSH) to S-nitrosoglutathione (GSNO)-treated cells, expressed as the mean ± SE (N = 7)
  2. b Represented by more than one probe set on the microarray that reached statistical significance; each result is shown