Phylogenetic tree built with PAD and NR database, with Danio-rerio's PAD sequence in out-group. This tree is the fusion on the NJ topology, of three phylogenetic trees built based on N eighbour Joining (NJ) , Maximum P arsimony (MP) , and Maximum L ikelihood (ML)  methods. The tree is labelled npl-A at the first root (for N j, mP, mL, with A ll topology congruence tests passed). For each node, bootstrap values are reported for each npl method. A "*" means that the bootstrap value was under 50%. PAD protein from Danio-Rerio is co-orthologous to all others PADs. In mammals five groups of orthologs are found, named PAD-1, PAD-2, PAD-3, PAD-4 and PAD-6. PAD-2 paralogy group is the best conserved as it evolved slower than the others.