Comparison of the deduced translated sequences for zebrafish progranulin-1 and progranulin-2. Two zebrafish cDNAs sharing 92.3% identity (grn1 and grn2), each possessing a 441 nucleotide-long open reading frame (ORF), encode deduced precursors consisting of one full and one amino-terminal half granulin peptide, with a calculated mass of 14.5 kDa and 14.8 kDa, respectively. Both carry an identical signal peptide (italics), whose predicted cleavage site is indicated by an arrow. The predicted sequences for zebrafish granulins 1 and 2 are highlighted. Numbers correspond to amino acid position.