Sequence comparison of zebrafish progranulin-A and -B with human progranulin. Amino acid sequences were deduced from the cloned grna and grnb zebrafish cDNAs. Unlike human progranulin, which carries one-half and seven granulin peptide motifs, zebrafish progranulin-a and progranulin-b harbour 10 and 9 full copies of the granulin motif (boxed), and possess distinct putative signal peptides (italics). Sequences were aligned using the ClustalW method, and gaps were introduced as dashed lines for optimal alignment. Identical residues are indicated by an asterisk. Numbers on the right represent amino acid position. Human granulin motif nomenclature is listed (right).