TY - JOUR AU - Stefan, Mihaela AU - Claiborn, Kathryn C. AU - Stasiek, Edyta AU - Chai, Jing-Hua AU - Ohta, Tohru AU - Longnecker, Richard AU - Greally, John M. AU - Nicholls, Robert D. PY - 2005 DA - 2005/11/09 TI - Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes JO - BMC Genomics SP - 157 VL - 6 IS - 1 AB - Prader-Willi and Angelman syndrome (PWS and AS) patients typically have an ~5 Mb deletion of human chromosome 15q11-q13, of opposite parental origin. A mouse model of PWS and AS has a transgenic insertion-deletion (TgPWS/TgAS) of chromosome 7B/C subsequent to paternal or maternal inheritance, respectively. In this study, we define the deletion endpoints and examine the impact on expression of flanking genes. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-6-157 DO - 10.1186/1471-2164-6-157 ID - Stefan2005 ER -