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Table 1 Brain microarray data for mouse chromosome 7B2-C genesa in TgPWS vs. WT mice.

From: Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes

GenBank Affy ID Gene mRNA levelb Chr. 7 location (Mb and/or cM)
    TgPWS WT  
I. Genes centromeric of the TgPWS/TgAS deletion
NM_008087 94337_at Gas2 4.3 (3/5) 5.0 (2/5) 39.3 Mb; 26.8 cM
  94338_g_at Gas2 43.1 (5/5) 42.92 (5/5) as above
AK049836 97539_at Hrmt1l3 50.2 (5/5) 44.5 (4/5) 37.25 Mb
NM_016865 103671_at Htatip2 23.8 (0/5) 21.0 (0/5) 37.2 Mb
AY957576 103202_f_at E2F8 35.3 (4/5) 30.4 (4/5) 36.3 Mb
  103204_r_at E2F8 27.4 (1/5) 21.6 (2/5) as above
NM_013808 103084_at Csrp3 4.6 (0/5) 3.2 (0/5) 36.3 Mb
NM_013643 100406_at Ptpn5 399.8 (5/5) 406.1 (5/5) 34.5 Mb
NM_016855 95304_at Attp 8.5 (0/5) 8.7 (0/5) 34.3 Mb
NM_021884 94809_at Tsg101 56.5 (5/5) 56.6 (5/5) 34.3 Mb
NM_013580 93103_at Ldh3 1.7 (0/5) 1.3 (0/5) 34.3 Mb; 23.5 cM
II. Genes telomeric of the TgPWS/TgAS deletion
NM_007390 101131_at Chrna7 86.8 (0/5) 87.1 (0/5) 50.1 Mb; 30.0 cM
NM_021366 160617_at Klf13 145.2 (5/5) 155.6 (5/5) 50.9 Mb
NM_018752 102251_at Trpm1 77.7 (1/5) 56.7 (0/5) 51.2 Mb; 27.0 cM
BC055074 93235_at BB128963 51.3 (5/5) 46.0 (5/5) 51.3 Mb
NM_026483 104022_at Mphosph10 35.9 (0/5) 34.0 (0/5) 51.4 Mb
NM_028626 102022_at Mcee 79.6 (5/5) 81.1 (5/5) 51.4 Mb
NM_007461 92727_at Apba2 433.9 (5/5) 455.8 (5/5) 51.5 Mb; 25.5 cM
NM_009386 99935_at Tjp1 185.3 (5/5) 142.5 (5/5) 52.3 Mb; 28.5 cM
D50060 101196_at Pace4 78.3 (0/5) 71.2 (0/5) 52.9 Mb; 28.5 cM
NM_021336 101506_at Snrpa1 131.2 (5/5) 126 (5/5) 53.1 Mb
NM_024439 94245_at H47 141.8 (5/5) 144.2 (5/5) 53.1 Mb; 28.5 cM
NM_053080 98372_at Aldh1a3 13.3 (0/5) 9.8 (0/5) 53.4 Mb
NM_194070 93852_at Mef2a 399.9 (5/5) 417.4 (5/5) 54.3 Mb; 33.0 cM
AF056187 102224_at Igf1r 381.6 (5/5) 339.6 (5/5) 55.0 Mb; 33.0 cM
  1. a The primary microarray data from this experiment were reported in reference 15. As summarized in Fig. 1A, reference 15 included the data for the imprinted genes within the TgPWS/TgAS deletion that are on the MG-U74Av2 chip (Snrpn, Ndn, Magel2, Mkrn3 and Ube3a) and for non-imprinted genes within the deletion (Cyfip1, Herc2, and Gabrb3, although the latter transcript was not detectable; the p gene is also represented on the chip although not detectable in TgPWS or WT mice, and not previously reported). Additionally, a cluster of chromosome 18B3 genes were found to be abnormally expressed in TgPWS mice [15]. b mRNA levels are presented as the medians of Signal (relative abundance of a transcript), for TgPWS (n = 5) and WT (n = 5), with the number of calls as "detected" out of 5 comparison experiments in parentheses.
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