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Table 1 Brain microarray data for mouse chromosome 7B2-C genesa in TgPWS vs. WT mice.

From: Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes

GenBank

Affy ID

Gene

mRNA levelb

Chr. 7 location (Mb and/or cM)

   

TgPWS

WT

 

I. Genes centromeric of the TgPWS/TgAS deletion

NM_008087

94337_at

Gas2

4.3 (3/5)

5.0 (2/5)

39.3 Mb; 26.8 cM

 

94338_g_at

Gas2

43.1 (5/5)

42.92 (5/5)

as above

AK049836

97539_at

Hrmt1l3

50.2 (5/5)

44.5 (4/5)

37.25 Mb

NM_016865

103671_at

Htatip2

23.8 (0/5)

21.0 (0/5)

37.2 Mb

AY957576

103202_f_at

E2F8

35.3 (4/5)

30.4 (4/5)

36.3 Mb

 

103204_r_at

E2F8

27.4 (1/5)

21.6 (2/5)

as above

NM_013808

103084_at

Csrp3

4.6 (0/5)

3.2 (0/5)

36.3 Mb

NM_013643

100406_at

Ptpn5

399.8 (5/5)

406.1 (5/5)

34.5 Mb

NM_016855

95304_at

Attp

8.5 (0/5)

8.7 (0/5)

34.3 Mb

NM_021884

94809_at

Tsg101

56.5 (5/5)

56.6 (5/5)

34.3 Mb

NM_013580

93103_at

Ldh3

1.7 (0/5)

1.3 (0/5)

34.3 Mb; 23.5 cM

II. Genes telomeric of the TgPWS/TgAS deletion

NM_007390

101131_at

Chrna7

86.8 (0/5)

87.1 (0/5)

50.1 Mb; 30.0 cM

NM_021366

160617_at

Klf13

145.2 (5/5)

155.6 (5/5)

50.9 Mb

NM_018752

102251_at

Trpm1

77.7 (1/5)

56.7 (0/5)

51.2 Mb; 27.0 cM

BC055074

93235_at

BB128963

51.3 (5/5)

46.0 (5/5)

51.3 Mb

NM_026483

104022_at

Mphosph10

35.9 (0/5)

34.0 (0/5)

51.4 Mb

NM_028626

102022_at

Mcee

79.6 (5/5)

81.1 (5/5)

51.4 Mb

NM_007461

92727_at

Apba2

433.9 (5/5)

455.8 (5/5)

51.5 Mb; 25.5 cM

NM_009386

99935_at

Tjp1

185.3 (5/5)

142.5 (5/5)

52.3 Mb; 28.5 cM

D50060

101196_at

Pace4

78.3 (0/5)

71.2 (0/5)

52.9 Mb; 28.5 cM

NM_021336

101506_at

Snrpa1

131.2 (5/5)

126 (5/5)

53.1 Mb

NM_024439

94245_at

H47

141.8 (5/5)

144.2 (5/5)

53.1 Mb; 28.5 cM

NM_053080

98372_at

Aldh1a3

13.3 (0/5)

9.8 (0/5)

53.4 Mb

NM_194070

93852_at

Mef2a

399.9 (5/5)

417.4 (5/5)

54.3 Mb; 33.0 cM

AF056187

102224_at

Igf1r

381.6 (5/5)

339.6 (5/5)

55.0 Mb; 33.0 cM

  1. a The primary microarray data from this experiment were reported in reference 15. As summarized in Fig. 1A, reference 15 included the data for the imprinted genes within the TgPWS/TgAS deletion that are on the MG-U74Av2 chip (Snrpn, Ndn, Magel2, Mkrn3 and Ube3a) and for non-imprinted genes within the deletion (Cyfip1, Herc2, and Gabrb3, although the latter transcript was not detectable; the p gene is also represented on the chip although not detectable in TgPWS or WT mice, and not previously reported). Additionally, a cluster of chromosome 18B3 genes were found to be abnormally expressed in TgPWS mice [15]. b mRNA levels are presented as the medians of Signal (relative abundance of a transcript), for TgPWS (n = 5) and WT (n = 5), with the number of calls as "detected" out of 5 comparison experiments in parentheses.
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BMC Genomics

ISSN: 1471-2164

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