Table 2 SIFT and PolyPhen predictions of the possible impact of 13 amino acid variants in the CMMB on protein structure and function.
From: Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice
Gene (protein ID) | Amino acid change | SIFT scorea | SIFT prediction | PolyPhen prediction |
|---|---|---|---|---|
Mc1r(NP_032585) | Phe256Ser | (0.00) | (Not Tolerated) | Possibly Damaging |
Scnm1(NP_081289) | Ile112Thr | (0.44) | (Tolerated) | Benign |
Usp29(NP_067298) | Glu124Lys | (0.05) | (Tolerated) | Benign |
Usp29(NP_067298) | Cys485Ser | 0.01 | Not Tolerated | Probably Damaging |
Usp29(NP_067298) | Lys679Arg | 0.05 | Tolerated | Benign |
Zim1(NP_035899) | Lys176Arg | 0.62 | Tolerated | Benign |
Zim1(NP_035899) | Lys246Glu | (0.30) | (Tolerated) | Benign |
Zim1(NP_035899) | Val460Glu | 0.18 | Tolerated | Benign |
Myd88(NP_034981) | Val175Met | 0.01 | Not Tolerated | Benign |
Myd88(NP_034981) | Ile273Lys | 0.29 | Tolerated | Probably Damaging |
Ap2a1(NP_031484) | Glu414Gly | 0.23 | Tolerated | Possibly Damaging |
Ap2a1(NP_031484) | Asn197Lys | 0.36 | Tolerated | Possibly Damaging |
Pak4(NP_081746) | Pro283Ser | 0.42 | Tolerated | Possibly Damaging |