Phylogenetic tree of the HET-C2/GLTP/ACD11 family of proteins. Tree reconstruction was performed as described in the Methods section. Experimentally characterized proteins are shown in yellow. The numbers indicate percent bootstrap values for selected internal branches. Hemiascomycete members including Debaryomyces hansenii, Ashbya gossypii, Yarrowia lipolytica, and Kluyveromyces lactis clustered together with the basidiomycete U. maydis.