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Table 3 Putative apoptotic mediators (fungal protein homologs)

From: Comparative analysis of programmed cell death pathways in filamentous fungi

Protein ASP SOR Scer Spom BAS Biological function/process
Aif1p 0 0 1 0 0 Caspase independent apoptosis
Stm1p 1 1 1 1 1 Caspase independent apoptosis
Cdc6p 1 1 1 1 1 Cell cycle control, DNA replication
Asf1p 1 0–1 1 1 1 Cell cycle, chromatin assembly, mating
Cdc13p 0 0 1 0 0 Cell cycle control, telomere-binding
Cyc1p 1 1 1 1 1 Electron transport, cytochrome c
Mre11p 1 1 1 1 1 Maintenance of genome integrity
Rad50p 1 1 1 1 1 Maintenance of genome integrity
Yca1p 2–3 1–4 1 1 1–2 Metacaspase
Sfk1p 1 1 1 1 1 Mitochondrial death pathway
Atp4p 1 1 1 1 1 Mitochondrial F1F0 ATP synthase
DAP3 1 1 1 1 1 Mitochondrial fragmentation
HtrA2 1 1–2 1 2 0 Mitochondrial homeostasis
Lsm4p 1 1 1 1 1 mRNA processing
Nsr1p 1 1 1 1 1 rRNA processing
Hel10p 1 0–1 1 0 0 Apoptosis
Uth1p 1 1 4 2 0 Response to stress
Sod1p 1 1 1 1 1 Response to stress
BI-1 1 1 1 1 1 Response to stress
Mras1 1 1 1 1 1 Regulation of development, signaling
FadA/GpaA 1 1 1 1 1 Regulation of sexual differentiation, sporulation, G-protein signaling
Ste4p/CGB1 1 1 1 1 1 Regulation of sexual differentiation, sporulation, G-protein signaling
Ste18p 1 1 1 1 1 Regulation of sexual differentiation
Ste20p 1 0–1 1 1 1 Regulation of sexual differentiation
Sip3p 1 1 2 1 0 Regulation of sexual differentiation
Sst2p, FlbA 1 1–2 1 1 1 Regulation of sexual differentiation
Oxa1 1 1 1 1 1 Regulation of life span, respiratory complex assembly
RMP1 1 1 1 1 1 Regulation of development and life span, respiratory complex assembly
Lag1p 1 1 1 2 1 Sphingolipid-mediated signaling
Sar1p, SarA 1 1 1 1 1 Ubiquitin-proteosome system
Cdc48p 1 1 1 1 1 Ubiquitin-proteosome system
Ubp10p 0 0–1 1 0 0 Ubiquitin-proteosome system
Ppa1p 1 1 1 1 0 Vacuolar ATPase subunit
  1. ASP, A. fumigatus, N. fischeri, A. oryzae, A. nidulans; SOR, N. crassa, G. zeae, and M. grisea; BAS: C. neoformans and U. maydis; Scer, S. cerevisiae; Spom, S. pombe.