Table 3 Putative apoptotic mediators (fungal protein homologs)
From: Comparative analysis of programmed cell death pathways in filamentous fungi
Protein | ASP | SOR | Scer | Spom | BAS | Biological function/process |
|---|---|---|---|---|---|---|
Aif1p | 0 | 0 | 1 | 0 | 0 | Caspase independent apoptosis |
Stm1p | 1 | 1 | 1 | 1 | 1 | Caspase independent apoptosis |
Cdc6p | 1 | 1 | 1 | 1 | 1 | Cell cycle control, DNA replication |
Asf1p | 1 | 0–1 | 1 | 1 | 1 | Cell cycle, chromatin assembly, mating |
Cdc13p | 0 | 0 | 1 | 0 | 0 | Cell cycle control, telomere-binding |
Cyc1p | 1 | 1 | 1 | 1 | 1 | Electron transport, cytochrome c |
Mre11p | 1 | 1 | 1 | 1 | 1 | Maintenance of genome integrity |
Rad50p | 1 | 1 | 1 | 1 | 1 | Maintenance of genome integrity |
Yca1p | 2–3 | 1–4 | 1 | 1 | 1–2 | Metacaspase |
Sfk1p | 1 | 1 | 1 | 1 | 1 | Mitochondrial death pathway |
Atp4p | 1 | 1 | 1 | 1 | 1 | Mitochondrial F1F0 ATP synthase |
DAP3 | 1 | 1 | 1 | 1 | 1 | Mitochondrial fragmentation |
HtrA2 | 1 | 1–2 | 1 | 2 | 0 | Mitochondrial homeostasis |
Lsm4p | 1 | 1 | 1 | 1 | 1 | mRNA processing |
Nsr1p | 1 | 1 | 1 | 1 | 1 | rRNA processing |
Hel10p | 1 | 0–1 | 1 | 0 | 0 | Apoptosis |
Uth1p | 1 | 1 | 4 | 2 | 0 | Response to stress |
Sod1p | 1 | 1 | 1 | 1 | 1 | Response to stress |
BI-1 | 1 | 1 | 1 | 1 | 1 | Response to stress |
Mras1 | 1 | 1 | 1 | 1 | 1 | Regulation of development, signaling |
FadA/GpaA | 1 | 1 | 1 | 1 | 1 | Regulation of sexual differentiation, sporulation, G-protein signaling |
Ste4p/CGB1 | 1 | 1 | 1 | 1 | 1 | Regulation of sexual differentiation, sporulation, G-protein signaling |
Ste18p | 1 | 1 | 1 | 1 | 1 | Regulation of sexual differentiation |
Ste20p | 1 | 0–1 | 1 | 1 | 1 | Regulation of sexual differentiation |
Sip3p | 1 | 1 | 2 | 1 | 0 | Regulation of sexual differentiation |
Sst2p, FlbA | 1 | 1–2 | 1 | 1 | 1 | Regulation of sexual differentiation |
Oxa1 | 1 | 1 | 1 | 1 | 1 | Regulation of life span, respiratory complex assembly |
RMP1 | 1 | 1 | 1 | 1 | 1 | Regulation of development and life span, respiratory complex assembly |
Lag1p | 1 | 1 | 1 | 2 | 1 | Sphingolipid-mediated signaling |
Sar1p, SarA | 1 | 1 | 1 | 1 | 1 | Ubiquitin-proteosome system |
Cdc48p | 1 | 1 | 1 | 1 | 1 | Ubiquitin-proteosome system |
Ubp10p | 0 | 0–1 | 1 | 0 | 0 | Ubiquitin-proteosome system |
Ppa1p | 1 | 1 | 1 | 1 | 0 | Vacuolar ATPase subunit |