Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites

BMC Genomics

Table 2 Conserved Cytoplasmic Dynein Subunits in Apicomplexans

		*Toxoplasma gondll*(Tg)				*Plasmodium falciparum*(Pf)				*Cryptosporidium parvum*(Cp)				*Thelleria parva*(Tp)
Dynein Subunit	Pfam ID	Tg Candidate^a	Top Match^b	E -value ^c	Pfam Score^d	Pf Candidate^a	Top Match^b	E -value ^c	Pfam Score^d	Cp Candidate^a	Top Match^b	E -value ^c	Pfam Score^d	Tp Candidate^a	Top Match^b	E -value^c	Pfam Score^d
Heavy Chain	pfam03028	TgTwinScan_0436	Rn heavy chain	0	402	CAD51040	Rn heavy chain	0	297	EAK88498	Dm heavy chain	0	274	CAI73268 ^{e, f}	Ce heavy chain	2.00 × 10 ^-76	76.1
Light Chain	pfam01221	TgTwinScan_2634	Mm light chain2	6.00 × 10 ^-24	148	AAN36221	Rn light chain	1.00 × 10 ^-38	130	EAL37552 ^{g, h}	Dm light chain 1	4.00 × 10 ^-41	142	EAN33478	Rn light chain	2.00 × 10 ^-27	111
Intermediate Chain	nd	TgTwinScan_1768	Xt intermediate chain	7.00 × 10 ^-80		AAN35394	Dd intermediate chain	1.00 × 10 ^-82		EAK88439	Xt intermediate chain	1.00 × 10 ^-48		-	-	-	-
Intermediate Light Chain	pfam05783	TgTwinScan_4175	Hs intermediate light chain	8.00 × 10 ^-07	63.9	CAD51749	Gg intermediate light chain	3.00 × 10 ^-10	72	EAK88297	Gg intermediate light chain	0.023	43.5	-	-	-	-
Dynein Light Chain TcTex1	pfam03645	TgTwinScan_1459	Hs TcTex1	2.00 × 10 ^-12	81	CAD51956	Hs TcTex1	1.00 × 10^-12	70.3	EAK87898	Mm TcTex1	9.00 × 10 ^-17	83.4	-	-	-	-
Roadblock	pfam03259	TgTwinScan_6940	Ci roadblock	6.00 × 10 ^-34	81.8	AAN35393	Ci roadbloack	1.00 × 10 ^-24	85.3	EAK88245	Ci roadblock	0.24	-	-	-	-	-

nd = not defined
(-) = no significant match
a = gene candidates identified by text and BLASTP searches of http://www.ToxoDB.org, http://www.PlasmoDB.org, http://www.CryptoDB.org, and the NCBI nr database
b = identifying protein found in reciprocal BLASTP search of the NCBI nr database using apicomplexan candidates as query
c = E -value of reciprocal BLASTP search
d = Pfam score as determined by BLASTP comparison to the CDD NCBI database
e = Theileria annulata
f = Tp ortholog EAN34073
g = Cryptosporidium hominis
h = Cp ortholog encoded on contig_AAEE01000005 nt#75605–75871frame1. Translated using GENESCAN webserver
Ce = Caenorhabditis elegans, Ci = Ciona intestinalis, Dd = Dictyostelium discoideum, Dm = Drosophila melanogaster, Hs = Homo sapien, Gg = Gallus gallus, Mm = Mus musculus, Rn = Rattus norvegicus, Xt = Xenopus tropicalis

ISSN: 1471-2164