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Table 3 Conserved Dynactin Subunits in Apicomplexans

From: Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites

   Toxoplasma gondii(Tg) plasmodium falciparum(Pf) Crytosporidium parvam(Cp)
Dynactin Subunit Pfam ID Tg Candidatea Top Matchb E -value c Pfam scored Pf Candidatea Top Matchb E -value c Pfam scored Cp Candidatea Top Matchb E -value c Pfam scored
Arp1 * pfam00022 TgArp1 TgTwinScan_4250 GgArp1 1.00 × 10 -147 492 PfArp1 CAD48998 Gg Arp1 1.00 × 10-141 464 CpArp1 EAK87959 GgArp1 1.00 × 10 -131 437
Arp10/11 * pfam00022 TgALP3 TgTwinScan_2515 Gg Arp10 8.00 × 10 -28 80.8 PfALP3 CAD51025 Dr Arp10 8.00 × 10 -05 - CpALP3 EAK89329 GgArp10 9.00 × 10 -21 73.1
p62 e pfam05502 TgTwinScan_5099 Hs p62 3.00 × 10 -09 62.8 AAN37118 Hs p62 5.00 × 10 -05 56.7 EAK88826 Hs p62 9.00 × 10 -21 101
p25 f nd TgTwinScan_4906 Gg p25 4.00 × 10 -29   CAD50982 Dd p25 2.00 × 10 -21   EAK87596 Dd p25 9.00 × 10 -18  
p27 g nd TgTwinScan_1451 Sp p27 8.00 × 10 -05   CAD51191 Bt p27 0.009   EAK90307 Am p27 9.00 × 10 -08  
CapZ α pfam01267 AAU93918 At CapZ α 1.3 - CAD51646 Dd CapZ α 4.00 × 10 -17 102 - - -  
CapZ β pfam01115 AAU93916 Dm CapZ β 2.00 × 10 -45 197 CAD51540 Dm CapZ β 4.00 × 10 -29 140 EAK88546 Dd CapZ β 2.00 × 10 -07 53.9
Dynamitin/p5O h pfam04912 TgTwinScan_4110 Dr p5O 4.00 × 10 -10 62 CAD52583 XI p5O 1.00 × 10 -04 52.8 - - - -
  1. * = see phylogenetic analysis for definition of apicomplexan candidates
  2. nd = not defined
  3. (-) = no significant match
  4. a = protein ID of candidate apicomplexan protein
  5. b = identifying protein found in reciprocal search of the NCBI database using the apicomplexan candidate as query
  6. c = E -value of the top match identifying protein in comparison to the apicomplexan candidate
  7. d = Pfam score as determined by BLASTP comparison to the CDD NCBI database
  8. e = protein sequences used to identify apicomplexan candidates : Hs AAH26323, Dm AAF59211, Ce AAC24257, Dd XP_641285
  9. f = protein sequences used to identify apicomplexan candidates: Hs Q9BTE1, Dm AAF34709, Sp XP_782293, Dd EAL68462
  10. g = protein sequences used to identify apicomplexan candidates : Hs AAH13175, Dm NP_609949, Ce NP_491116
  11. h = protein sequences used to identify apicomplexan candidates : Hs AAC50423, Dm AAF59034, Ce NP_498286, Dd XP_638093
  12. Am = Apis melliferous, At = Arabidopsis thaliana, Bt = Bos taurus, Ce = Caenorhabditis elegans, Dd = Dictyostelium discoideum, Dm = Drosophila melanogaster, Dr = Danio rerio, Hs = Homo sapiens, Gg = Gallus gallus, Sp = Strongylocentrotus purpuratus, XI = Xenopus laevis