Figure 1

Multiple sequence alignment of selected representatives of the extended COG4636+ family. The selection of representative sequences includes the modeled protein from Nostoc (motif H-PD-EXX-K, members from G. violaceus with different order of putative catalytic residues (Gv1: H-PD-EXK; Gv2: S-PD-EXD-K; Gv3: H-PD-EXD; Gv4: H-PD-EXX-N; Gv5: Q-PD-EXX-K), and members of mono-phyletic clusters from D. hafniense, C. aurantiacus, S. coelicolor, T. thermophilus, and G. violaceus). The positions of putative catalytic residues are labeled with "*". The variable termini, which could not be confidently aligned, are not shown; the number of omitted residues is indicated. A complete alignment of full-length sequences is available for download from ftp://genesilico.pl/iamb/models/COG4636/. Amino acids are colored according to the physico-chemical properties of their side-chains (negatively charged: red, positively charged: blue, polar: magenta, hydrophobic: green). Conserved residues are highlighted. Elements of predicted secondary structure (helices and strands) are indicated by tubes and arrows, respectively.