TY - JOUR AU - Da Silva, Melissa AU - Upton, Chris PY - 2005 DA - 2005/02/18 TI - Using purine skews to predict genes in AT-rich poxviruses JO - BMC Genomics SP - 22 VL - 6 IS - 1 AB - Clusters or runs of purines on the mRNA synonymous strand have been found in many different organisms including orthopoxviruses. The purine bias that is exhibited by these clusters can be observed using a purine skew and in the case of poxviruses, these skews can be used to help determine the coding strand of a particular segment of the genome. Combined with previous findings that minor ORFs have lower than average aspartate and glutamate composition and higher than average serine composition, purine content can be used to predict the likelihood of a poxvirus ORF being a "real gene". SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-6-22 DO - 10.1186/1471-2164-6-22 ID - Da Silva2005 ER -