Figure 7
Classification of formins according to structural and functional elements. Most formins of metazoans as well as formins of Dictyostelium and fungi can be classified as conventional formins, with a GBD/FH3-FH1-FH2-DAD structure, although in particular members or alternatively spliced variants a domain (but never the FH2) might be absent. Plant formins can be grouped into one of two classes. Delphilin is an unconventional formin lacking GBD/FH3 and DAD only found in metazoa. Formins are not drawn to scale. SP, signal peptide. TM, transmembrane region.