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Figure 3 | BMC Genomics

Figure 3

From: Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus

Figure 3

Domain expansion of Psg24 , Psg30 and Psg31. A. NJ-trees based on ClustalX amino acid sequence alignments showing: (i) the evolution of PSG24 IgV-like domains compared to those of PSG17; (ii) the evolution of PSG30 IgV-like domains compared to those of PSG17; (iii) the evolution of PSG31 IgV-like domains compared to those of PSG17. The trees were rooted using an outgroup consisting of the N-domain amino acid sequences of human PSG1, PSG2 and PSG3. Alignments were bootstrapped 1000 times yielding node values which are represented as follows < 50%: no mark; 50–74%: marked *; 75–94%: marked **; ≥ 95%: marked ***. The scale bar represents 0.1 amino acid substitutions per site. B. The arrangement of domains represented by boxes shaded: cyan for leader (L) peptides; light pink for the N1-domains; dark pink for N2 and N2-like domains; red for N3 and N3-like domains; blue for A-domains. (i) Comparison of Psg17 and Psg24 exon arrangement including identities of amino acid sequence alignments. (ii) Comparison of Psg30 and Psg31 exon arrangements including identities of amino acid sequence alignments. C. Predicted model of IgV-like domain expansion by exon duplications in (i) Psg24 and (ii) Psg30 and Psg31.

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