Figure 6
From: A gene expression fingerprint of C. elegans embryonic motor neurons
Model of DA motor neuron axon guidance. Ventrally derived UNC-6/Netrin guidance cues binds to the UNC-40/DCC and UNC-5 receptor to steer the DA motor axon toward the dorsal nerve cord. The receptor tyrosine phosphatase, CLR-1, promotes dorsal motor axon outgrowth via an UNC-40/DCC independent pathway [24]. The transcript encoding the C. elegans ortholog of Abelson tyrosine kinase (ABL-1) is enriched in the unc-4::GFP motor neuron data set and is proposed to antagonize CLR-1 activity.