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Table 2 Detailed information related to genes in osteogenic differentiation

From: Osteo-Promoter Database (OPD) – Promoter analysis in skeletal cells

GENE PROTEIN CELLULAR FUNCTION DISEASE LOCUS ACCESSION NUMBER PROMOTER
BGLAP Bone gamma-carboxyglutamate (gla) protein (osteocalcin) Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.   1q25-q31 P-NP_000702
N-NM_000711
U-Hs.2558
AY147065
BGN Biglycan Binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival. Happle syndrome Xq28 P-NP_001702
N-NM_001711
U-Hs.821
U82940
X83526
BMP4 Bone morphogenetic protein 4 Involved in bone induction & tooth development Fibrodysplasia ossificans progressiva 14q22-q23 P-NP_001193
N-NM_001202
U-Hs.68879
AH007194
AF210053
CBFA1 Core-binding factor alpha-subunit 1 Osteoblast-specific transcription factor Cleidocranial dysplasia murine Cbfa1+/- cleidocranial dysplasia murine Cbfa1-/- perinatal lethal with deficient ossification of skeleton 6p21 P-NP_004339
N-NM_004348
U-Hs.121895
AB013356
ESR1 Estrogen receptor 1 (ER alpha) Activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes.   6q25.1 P-NP_004442
N-NM_004451
U-Hs.110849
X62462
PRLR Prolactin receptor This is a receptor for the anterior pituitary hormone prolactin   5p14-p13 P- NP_000940
N-NM_000949
U-Hs.1906
AF091859
  1. List of factors such as transcription factors, hormones and matrix proteins play a role mediating of osteoblast differentiation.