Table 2 Detailed information related to genes in osteogenic differentiation

BGLAP

Bone gamma-carboxyglutamate (gla) protein (osteocalcin)

Gamma-carboxyglutamic acid residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

1q25-q31

P-NP_000702

N-NM_000711

U-Hs.2558

AY147065

BGN

Biglycan

Binding to collagen fibrils and transfering growth factor-beta. It may promote neuronal survival.

Happle syndrome

Xq28

P-NP_001702

N-NM_001711

U-Hs.821

U82940

X83526

BMP4

Bone morphogenetic protein 4

Involved in bone induction & tooth development

Fibrodysplasia ossificans progressiva

14q22-q23

P-NP_001193

N-NM_001202

U-Hs.68879

AH007194

AF210053

CBFA1

Core-binding factor alpha-subunit 1

Osteoblast-specific transcription factor

Cleidocranial dysplasia murine Cbfa1+/- cleidocranial dysplasia murine Cbfa1-/- perinatal lethal with deficient ossification of skeleton

6p21

P-NP_004339

N-NM_004348

U-Hs.121895

AB013356

ESR1

Estrogen receptor 1 (ER alpha)

Activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes.

6q25.1

P-NP_004442

N-NM_004451

U-Hs.110849

X62462

PRLR

Prolactin receptor

This is a receptor for the anterior pituitary hormone prolactin

5p14-p13

P- NP_000940

N-NM_000949

U-Hs.1906

AF091859