Figure 10

Inhibition of MagT1-mediated currents. A,inhibition of Mg²⁺-evoked currents with 0.2 mM test cation in the presence of external 2.0 mM Mg²⁺. For clarity, only Cu²⁺, Mn³⁺, and Zn²⁺ relative to Mg²⁺ are represented. Values are mean ± SEM of currents measured at the end of each voltage sweep for the respective cation. B, summary of inhibition by multivalent cations of Mg²⁺ currents based on the change in E_rev represented in Fig. 10A. The inhibitor was added with MgCl₂ and voltage-clamp was performed about 5 min later.