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Table 4 Molecular function classification of 175 genes derived from three analyses. As in Table 3, the gene names from three analyses were annotated according to the Gene Ontology Molecular Function categories. Not shown are genes multiply annotated into additional singular categories or genes absent from the Gene Ontology. Percentages were calculated from a total of 251 gene classifications into 52 Molecular Function terms.

From: Expression analysis of secreted and cell surface genes of five transformed human cell lines and derivative xenograft tumors

GO Function % Genes
GO:0004872 receptor activity 20.3% PTGER3 CD44 TAS2R16 GALR2 OR1F1 SORCS3 FZD1 GFRA3 CXCR4 APOB48R SSTR3 OPCML TRPV2 GPR145 GPR44 EPHA3 GPA33 TNC GPR80 EBI2 TSHR F2R NRP1 MC2R OR7A17 AGTR2 HLA-A GPR48 OR1F10 CHRM1 GPR10 GPR57 GPR6 CCR5 ADCYAP1R1 GPR23 IFNGR2 OGFR APMCF1 GPR110 CR1 KLRB1 IGSF6 ADORA2B IL12B GPLD1 FPR1 CCR4 NPY1R ESR1 ITGA4
GO:0005102 receptor binding 10.8% HDGF BDNF SELPLG GFRA3 IL26 ENSA EFNA1 EDN3 F2R INHBB IL8 CXCL1 SPP1 CXCL11 IL7 NOV PYY CXCL2 FGF23 PBEF FBLN5 FGF19 STC2 ANGPT2 PF4 IL12B KITLG
GO:0016787 hydrolase activity 7.6% RNASE1 LIPF MMP7 KLK11 CMA1 MMP10 FAP PRSS11 RNASE6 MMP8 PCSK5 RAP2B RNASE4 KLK13 ADAM28 FIBL-6 TLL1 GPLD1 GNAO1
GO:0005515 protein binding 7.6% CD44 TMPO IGFBP3 CXCR4 LTBP1 PRSS11 INHBB IGFBP7 PI3 MGC2376 A2M NID2 CCR5 IFNGR2 SERPINA4 NOV PLEC1 FN1 CCR4
GO:0046872 metal ion binding 6.0% FSTL1 MMP7 TF CACNA1H BGLAP MMP10 LTBP1 MMP8 CP NID2 PCDHB9 ADAM28 FIBL-6 FBLN5 TLL1
GO:0042277 peptide binding 6.0% GALR2 SORCS3 CXCR4 SSTR3 OPCML GPR44 F2R MC2R AGTR2 GPR10 CCR5 OGFR FPR1 CCR4 NPY1R
GO:0005201 extracellular matrix structural constituent 4.8% COL5A1 COL4A1 COL9A1 COL14A1 MAGP2 TFPI2 COL5A2 AMELY COL1A1 COL12A1 FN1 MFAP3
GO:0004857 enzyme inhibitor activity 3.6% SPINK2 SERPINC1 TFPI2 PI3 AGTR2 A2M TIMP3 SERPINA4 CST7
GO:0015267 channel/pore class transporter activity 2.8% TRPV2 CACNA1H CLCA4 MGC2376 CHRM1 TRPM5 HCN2
GO:0005539 glycosaminoglycan binding 2.8% HDGF FSTL1 CD44 COL5A1 SERPINC1 FN1 PF4
GO:0003676 nucleic acid binding 2.4% TMPO RNASE1 APOB48R RNASE6 RNASE4 ESR1
GO:0000166 nucleotide binding 2.4% EPHA3 FLJ20559 RAP2B APMCF1 HCN2 GNAO1
GO:0016740 transferase activity 2.4% EPHA3 HAS1 GP3ST FLJ20559 NRP1 FUT8
GO:0004895 cell adhesion receptor activity 1.6% CD44 TNC GPLD1 ITGA4
GO:0015075 ion transporter activity 1.6% TRPV2 SLC39A4 CP SLC16A8
GO:0016301 kinase activity 1.2% EPHA3 FLJ20559 NRP1
GO:0030246 carbohydrate binding 0.8% CHODL KLRB1
GO:0005386 carrier activity 0.8% A2M SLC16A8
GO:0005180 peptide hormone 0.8% PYY STC2
GO:0008565 protein transporter activity 0.8% SORCS3 SCAMPI
GO:0008147 structural constituent of bone 0.8% BGLAP COL1A1
GO:0003800 antiviral response protein activity 0.4% IFNGR2
GO:0008189 apoptosis inhibitor activity 0.4% SPP1
GO:0015457 auxiliary transport protein activity 0.4% ENSA