TY - JOUR AU - Urcelay, Elena AU - Santiago, José L. AU - de la Calle, Hermenegildo AU - Martínez, Alfonso AU - Méndez, Julián AU - Ibarra, José M. AU - Maluenda, Carlos AU - Fernández-Arquero, Miguel AU - de la Concha, Emilio G. PY - 2005 DA - 2005/04/20 TI - Type 1 Diabetes in the Spanish Population: additional factors to Class II HLA-DR3 and -DR4 JO - BMC Genomics SP - 56 VL - 6 IS - 1 AB - The Major Histocompatibility Complex is the main genetic contributor to susceptibility to type 1 diabetes (T1D); genome-wide scans have consistently mapped increased predisposition to this region. The highest disease risk has been associated with HLA-DR3 and HLA-DR4. In particular, the DR3-positive ancestral haplotype 18.2 was reported as highly diabetogenic. We aimed to corroborate whether this haplotype increases the susceptibility conferred by the DQ2-DR3 alleles in a Mediterranean population. We also searched for additional susceptibility factors to the classic DQ2-DR3 and DQ8-DR4. SN - 1471-2164 UR - https://doi.org/10.1186/1471-2164-6-56 DO - 10.1186/1471-2164-6-56 ID - Urcelay2005 ER -