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Table 2 Frequency and number of DR3-positive haplotypes estimated by the Arlequin software.

From: Type 1 Diabetes in the Spanish Population: additional factors to Class II HLA-DR3 and -DR4

 

T1D (2n = 596)

Controls (2n = 1006)

 

Freq.

Haplotypes

Freq.

Haplotypes

DR3-Total

0.39432

235

0.13120

132

I. DR3-a1b5

0.17276

103

0.03802

38

II. DR3-a2b3

0.10244

61

0.04866

49

III. DR3-other

0.11912

71

0.04452

45

  1. I vs. II+III. OR = 1.93 (1.19–3.13); p = 0.004.
  2. I vs. II. OR = 2.18 (1.24–3.83); p = 0.004.
  3. I vs. III. OR = 1.72 (0.98–3.01); p = 0.043.
  4. II vs. III. OR = 0.79 (0.45–1.39); p = 0.38.
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