Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

Table 1 Classification according to the Gene Ontology system of genes differentially regulated along the intestine.

GO description^a	Total (1-/G-F-Flag)^b	UGs on Chips^c	DJ^b,d	JI^b,d	IC^b,d	SI C^b,d
molecular function	2717 (1772/760/185)	6890	659	897	897	2055
transporter activity	350 (244/75/31)	853	95	115	126	263
amine/polyamine	18 (11/2/5)	35	8	7	11	14
auxiliary transport protein	2 (2/0/0)	2	0	0	1	1
carbohydrate	8 (5/1/2)	18	2	4	7	8
carrier activity	124 (91/10/24)	262	35	41	55	98
electrochemical potential-driven transporter	57 (43/9/5)	104	20	27	35	47
porter	56 (42/9/5)	103	20	26	35	47
antiporter	11 (10/0/1)	16	4	6	9	11
cation\:cation antiporter	5 (5/0/0)	6	2	2	2	5
symporter	30 (18/7/5)	51	10	12	16	26
solute\:cation symporter	19 (10/5/4)	31	5	8	9	17
solute\:Na symporter	17 (8/5/4)	26	4	7	8	14
channel/pore class	64 (40/5/19)	211	15	19	22	47
electron	36 (272/7)	65	10	12	16	29
ion transporter	68 (49/5/14)	151	20	18	25	55
Lipid	6 (3/2/1)	16	2	3	5	4
neurotransmitter	8 (4/2/2)	12	2	3	5	7
nb/ns./nt/nucleic acid	2 (2/0/0)	4	1	0	1	1
Organic acid	22 (13/2/7)	43	8	9	11	16
Oxygen	2 (2/0/0)	5	0	1	0	0
Peptide	3 (3/0/0)	5	1	2	2	2
permease	1 (1/0/0)	5	0	0	0	2
Protein	78 (51/9/18)	163	18	17	13	56
Vitamin/cofactor	3 (1/2/0)	7	1	2	2	2
Water	1 (0/0/1)	2	0	0	1	1

^aTransporter activity classes (depth 3) for which no changes were observed are not listed (number of UniGene clusters represented on the microarrays): amide (0), boron (0), drug (1), group translocator (0), lactone (0), nitric oxide (0), organic alcohol (0), peptidoglycan (0), siderochrome (0), toxin (0) and xenobiotic (0). ^bListed is the number of differentially regulated genes along the whole intestinal tract and more specifically between adjoining intestinal segments (p ≤ 0.05). Grey cells indicate significant changes in the GO nodes (p ≤ 0.05). ^cTotal number of UniGene clusters being represented on the three Mu74v2 GeneChips. ^dSum of all differentially expressed UniGene clusters, i.e., from type (1), (F) and (G).

ISSN: 1471-2164