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Table 1 Classification according to the Gene Ontology system of genes differentially regulated along the intestine.

From: Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

GO descriptiona Total (1-/G-F-Flag)b UGs on Chipsc DJb,d JIb,d ICb,d SI Cb,d
molecular function 2717 (1772/760/185) 6890 659 897 897 2055
    transporter activity 350 (244/75/31) 853 95 115 126 263
       amine/polyamine 18 (11/2/5) 35 8 7 11 14
       auxiliary transport protein 2 (2/0/0) 2 0 0 1 1
       carbohydrate 8 (5/1/2) 18 2 4 7 8
       carrier activity 124 (91/10/24) 262 35 41 55 98
          electrochemical potential-driven transporter 57 (43/9/5) 104 20 27 35 47
             porter 56 (42/9/5) 103 20 26 35 47
                antiporter 11 (10/0/1) 16 4 6 9 11
                   cation\:cation antiporter 5 (5/0/0) 6 2 2 2 5
                symporter 30 (18/7/5) 51 10 12 16 26
                   solute\:cation symporter 19 (10/5/4) 31 5 8 9 17
                      solute\:Na symporter 17 (8/5/4) 26 4 7 8 14
       channel/pore class 64 (40/5/19) 211 15 19 22 47
       electron 36 (272/7) 65 10 12 16 29
       ion transporter 68 (49/5/14) 151 20 18 25 55
       Lipid 6 (3/2/1) 16 2 3 5 4
       neurotransmitter 8 (4/2/2) 12 2 3 5 7
       nb/ns./nt/nucleic acid 2 (2/0/0) 4 1 0 1 1
       Organic acid 22 (13/2/7) 43 8 9 11 16
       Oxygen 2 (2/0/0) 5 0 1 0 0
       Peptide 3 (3/0/0) 5 1 2 2 2
       permease 1 (1/0/0) 5 0 0 0 2
       Protein 78 (51/9/18) 163 18 17 13 56
       Vitamin/cofactor 3 (1/2/0) 7 1 2 2 2
       Water 1 (0/0/1) 2 0 0 1 1
  1. aTransporter activity classes (depth 3) for which no changes were observed are not listed (number of UniGene clusters represented on the microarrays): amide (0), boron (0), drug (1), group translocator (0), lactone (0), nitric oxide (0), organic alcohol (0), peptidoglycan (0), siderochrome (0), toxin (0) and xenobiotic (0). bListed is the number of differentially regulated genes along the whole intestinal tract and more specifically between adjoining intestinal segments (p ≤ 0.05). Grey cells indicate significant changes in the GO nodes (p ≤ 0.05). cTotal number of UniGene clusters being represented on the three Mu74v2 GeneChips. dSum of all differentially expressed UniGene clusters, i.e., from type (1), (F) and (G).