Table 3 Top 50 most divergent genes by HNS in H. pylori strain J99 plus those additional genes >2 SD greater than the mean by DNS and top 50 by TNS
HNS order | J99 annotation | JHP # | 26695 # | DNS order | TNS order |
|---|---|---|---|---|---|
1 | hypothetical protein | JHP1300 | HP1408 | 9 | 1 |
2 | cag pathogenicity island protein (cag7) | JHP0476 | HP0527 | 2 | 2 |
3 | type I restriction enzyme (hsdS) | JHP1422 | NAH | 319 | 10 |
4 | vacuolating cytotoxin (vacA) paralog | JHP0556 | HP0609/10 | 3 | 5 |
5 | vacuolating cytotoxin (vacA) paralog | JHP0274 | HP0289 | 4 | 6 |
6 | vacuolating cytotoxin (vacA) paralog | JHP0856 | HP0922 | 7 | 9 |
7 | hypothetical protein | JHP0191 | HP0205 | 53 | 33 |
8 | hypothetical protein | JHP1044 | HP1116 | 10 | 14 |
9 | hypothetical protein | JHP0928 | NAH | 11 | 12 |
10 | hypothetical protein | JHP0305 | HP0322 | 5 | 8 |
11 | hypothetical protein | JHP0462 | HP0513 | 104 | 54 |
12 | cag island protein (cagA) | JHP0495 | HP0547 | 17 | 20 |
13 | type III restriciton enzyme (mod) | JHP1411 | HP1522 | 857 | 104 |
14 | hypothetical protein | JHP1070 | HP1142 | 60 | 27 |
15 | type II restriction enzyme (methyltransferase) | JHP1409 | NAH | 37 | 55 |
16 | DNA-directed RNA polymerase, beta subunit (rpoB) | JHP1121 | HP1198 | 50 | 23 |
17 | hypothetical protein | JHP0440 | HP0488 | 13 | 16 |
18 | multidrug resistance protein (spaB) | JHP0547 | HP0600 | 75 | 39 |
19 | hypothetical protein | JHP0110 | HP0118 | 64 | 21 |
20 | topoisomerase I (topA 3) | JHP0931 | NAH – check | 18 | 18 |
21 | hypothetical protein | JHP0842 | HP0906 | 42 | 29 |
22 | type I restriction enzyme (hsdR) | JHP1424 | HP1402 | 195 | 138 |
23 | type III restriction enzyme (res) | JHP1410 | HP1521 | 161 | 258 |
24 | outer membrane protein (omp26) | JHP1084 | HP1157 | 24 | 17 |
25 | hypothetical protein | JHP1285 | HP1371 | 55 | 58 |
26 | hypothetical protein | JHP0540 | NAH | 674 | 158 |
27 | hypothetical protein | JHP0942 | HP0996 | 6 | 13 |
28 | type III restriction enzyme (res) | JHP1297 | NAH | 30 | 63 |
29 | type I restriction enzyme R protein (hsdR) | JHP0416 | HP0464 | 63 | 105 |
30 | type I restriction enzyme (hsdS) | JHP0414 | NAH | 275 | 85 |
31 | cag pathogenicity island protein (cag8) | JHP0477 | HP0528 | 72 | 62 |
32 | hypothetical protein | JHP0668 | HP0731 | 110 | 64 |
33 | hypothetical protein | JHP0613 | HP0669 | 44 | 42 |
34 | type III restriction enzyme (mod) | JHP1296 | NAH | 121 | 190 |
35 | type I restriction enzyme R protein (hsdR) | JHP0784 | HP0846 | 244 | 48 |
36 | N-methylhydantoinase | JHP0632 | HP0696 | 20 | 44 |
37 | RNA polymerase sigma-70 factor (rpoD) | JHP0081 | HP0088 | 62 | 71 |
38 | vacuolating cytotoxin (vacA) | JHP0819 | HP0887 | 59 | 46 |
39 | hypothetical protein | JHP1113 | HP1187 | 274 | 28 |
40 | hypothetical protein | JHP0534 | HP0586 | 577 | 230 |
41 | type II restriction enzyme (methyltrasferase) | JHP1284 | NAH | 750 | 290 |
42 | translation initiation factor IF-2 (infB) | JHP0377 | HP1048 | 330 | 281 |
43 | restriction enzyme | JHP0164 | NAH | 88 | 47 |
44 | hypothetical protein | JHP0458 | HP0508 | 84 | 50 |
45 | role in outermembrane permeability (imp) | JHP1138 | HP1215/6 | 208 | 196 |
46 | DNA polymerase I (polA) | JHP1363 | HP1470 | 46 | 81 |
47 | iron(III) dicitrate transport protein (fecA) | JHP0626 | HP0686 | 38 | 89 |
48 | adenine specific DNA methyltransferase (mod) | JHP0244 | HP0260 | 236 | 122 |
49 | histidine and glutamine-rich metal-binding protein | JHP1321 | HP1432 | 15 | 4 |
50 | DNA transfer protein (cagE) | JHP0492 | HP0544 | 49 | 95 |
54 | hypothetical protein | JHP0336 | HP1089 | 27 | 51 |
62 | cag pathogenicity island protein (cag3) | JHP0471 | HP0522 | 21 | 35 |
64 | hypothetical protein | JHP0026 | HP0030 | 23 | 36 |
70 | urease beta subunit (urea amidohydrolase) (ureB) | JHP0067 | HP0072 | 32 | 37 |
82 | DNA mismatch repair protein (mutS) | JHP0565 | HP0621 | 45 | 227 |
84 | hypothetical protein | JHP0050 | HP0058 | 8 | 7 |
90 | hypothetical protein | JHP0174 | HP0187/8/6 | 29 | 88 |
95 | hypothetical protein | JHP0934 | NAH | 16 | 15 |
111 | iron(III) dicitrate transport protein (fecA) | JHP1426 | HP1400 | 28 | 78 |
120 | hypothetical protein | JHP0052 | HP0059 | 26 | 24 |
125 | hypothetical protein | JHP0074 | HP0080 | 12 | 32 |
145 | Outer membrane protein | JHP0438 | HP0486 | 22 | 67 |
154 | flagellin A (flaA) | JHP0548 | HP0601 | 34 | 40 |
160 | DNA repair protein (recN) | JHP1434 | HP1393 | 51 | 177 |
209 | cytochrome oxidase (cbb3 type) (fixN) | JHP0132 | HP0144 | 41 | 206 |
275 | hypothetical protein | JHP0299 | HP061/2 | 35 | 11 |
342 | hypothetical protein | JHP1033 | HP1106 | 36 | 262 |
384 | hypothetical protein | JHP1253 | HP1333 | 40 | 75 |
393 | hypothetical protein | JHP0940 | NAH | 39 | 53 |
398 | cag island protein (cagH) | JHP0489 | HP0541 | 47 | 137 |
402 | siderophore-mediated iron transport protein (tonB) | JHP1260 | HP1341 | 48 | 1260 |
541 | integrase/recombinase (xerD) | JHP0941 | HP0995 | 33 | 100 |
558 | cag island protein (cagT) | JHP0481 | HP0532 | 25 | 70 |
694 | hypothetical protein | JHP1042 | HP1115 | 14 | 25 |
828 | cag island protein (cagF) | JHP0491 | HP0543 | 52 | 170 |
990 | hypothetical protein | JHP0925 | NAH | 43 | 130 |
1355 | hypothetical protein | JHP0952 | HP0427 | 1 | 3 |
1463 | hypothetical protein | JHP0953 | NAH | 31 | 26 |
1490 | hypothetical protein | JHP0693 | HP0756 | 19 | 59 |