Table 1 Chromosome 11 status and morphology of the microcell hybrids (MCH) obtained after chromosome 11 transfer in parental NGP.1A.TR1 cells as determined by Bader and colleagues [10] and in this study
From: Positional and functional mapping of a neuroblastoma differentiation gene on chromosome 11
microcell hybrid subclone (NGP.1A.TR1 + chr 11) | chromosome 11 status (in addition to parental NGP.1A.TR1 11q-loss) | morphology | |
|---|---|---|---|
Bader et al. [10] | this study | ||
MCH574c4,c11,c13 | no additional changes | del(11)(pterp15.1) | more flattened, adherent cells, some short neuritic processes |
MCH574c10 | del(11)(q23.3) (MCT128.1, HBI 18P2) | del(11)(pterp15.1) | more flattened, adherent cells, some short neuritic processes |
MCH574c3 | del(11)(p15.5) (HRAS) | del(11)(pterp15.1) del(11)(pterp13) del(11)(q25qter) | non-adherent, spheroid cells, growing in cell clusters |