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Table 1 B6.CAST and HG.CAST speed congenic strains developed to isolate and characterize genome-wide QTL affecting growth and obesity

From: Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains

QTLa MMU Peak LOD cM (Mbp)b Full congenic named Abbreviation Min. interval (Mbp)e
Wg1 2 31 (52) B6.CAST-(D2Mit1-D2Mit160)N(6) B62P 3.8–84.8
    HG.CAST-(D2Mit1-D2Mit160)N(6) HG2P 3.8–84.8
    B6.CAST-(D2Mit322-D2Mit439)N(6) B62PM 42.9–92.0
    HG.CAST-(D2Mit322-D2Mit439)N(6) HG2PM 42.9–92.0
Wg2 2 59–83c B6.CAST-(D2Mit329-D2Mit490)N(6) B62M 74.9–138.6
Carp1   (115–150) HG.CAST-(D2Mit329-D2Mit490)N(6) HG2M 74.9–138.6
Cara1    B6.CAST-(D2Mit329-D2Mit457)N(6) B62D 74.9–181.8
Feml1    HG.CAST-(D2Mit329-D2Mit457)N(6) HG2D 74.9–181.8
Q1Ucd1 -w26 1 16 (35) HG.CAST-(D1Mit118-D1Mit250)N(6) HG1 4.0–70.6
Carfhg1 5 38 (100) HG.CAST-(D5Mit229-D5Mit158)N(6) HG5 30.7–114.2
Wg3 8 45 (98) HG.CAST-(D8Mit9-D8Mit198)N(6) HG8 70.2–104.1
Carfhg2 9 10 (30) HG.CAST-(D9Mit249-D9Mit133)N(6) HG9 9.1–84.2
Feml2 9 20 (48) HG.CAST-(D9Mit249-D9Mit133)N(6) HG9 9.1–84.2
Carp2
Wg4
Cara2
11 46–50 (80–90) HG.CAST-(D11Mit260-D11Mit255)N(6) HG11 61.9–114.3
Feml3
Carp3
Cara3
17 46–48 (70–76) HG.CAST-(D17Mit213-D17Mit142)N(6) HG17 14.8–77.3
  1. QTL, quantitative trait locus; MMU, mouse chromosome; LOD, log of the odds
  2. a QTL MGI [59] nomenclature. Q1Ucd1-w26 never received an official MGI name, because it only reached a suggestive level of significance; hg modifier QTL are in bold [24].
  3. b Mbp position according to the August 2005 mm7 UCSC [28] genome assembly (NCBI Build 35), peak LOD from [24].
  4. c In the linkage analysis performed in [24], the peak location for Wg2, Carp1, Cara1 and Feml1 was 59–63 cM (115–120 Mbp) in hg/hg F2 mice and 78–83 cM (135–150 Mbp) in +/+ F2 mice.
  5. d Full congenic name consists of three parts: 1. B6.CAST, indicates the recipient strain is B6 and the donor strain is CAST; HG.CAST, indicates the recipient strain is HG and the donor strain is CAST; 2. markers defining the minimal congenic interval; 3. the number of backcrosses used for speed congenic development.
  6. e Represents the minimum genomic region spanned by CAST donor alleles.