Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains

BMC Genomics

Table 1 B6.CAST and HG.CAST speed congenic strains developed to isolate and characterize genome-wide QTL affecting growth and obesity

QTL^a	MMU	Peak LOD cM (Mbp)^b	Full congenic name^d	Abbreviation	Min. interval (Mbp)^e
Wg1	2	31 (52)	B6.CAST-(D2Mit1-D2Mit160)N(6)	B62P	3.8–84.8
			HG.CAST-(D2Mit1-D2Mit160)N(6)	HG2P	3.8–84.8
			B6.CAST-(D2Mit322-D2Mit439)N(6)	B62PM	42.9–92.0
			HG.CAST-(D2Mit322-D2Mit439)N(6)	HG2PM	42.9–92.0
*Wg2*	2	59–83^c	B6.CAST-(D2Mit329-D2Mit490)N(6)	B62M	74.9–138.6
Carp1		(115–150)	HG.CAST-(D2Mit329-D2Mit490)N(6)	HG2M	74.9–138.6
Cara1			B6.CAST-(D2Mit329-D2Mit457)N(6)	B62D	74.9–181.8
Feml1			HG.CAST-(D2Mit329-D2Mit457)N(6)	HG2D	74.9–181.8
Q1Ucd1 -w26	1	16 (35)	HG.CAST-(D1Mit118-D1Mit250)N(6)	HG1	4.0–70.6
Carfhg1	5	38 (100)	HG.CAST-(D5Mit229-D5Mit158)N(6)	HG5	30.7–114.2
Wg3	8	45 (98)	HG.CAST-(D8Mit9-D8Mit198)N(6)	HG8	70.2–104.1
*Carfhg2*	9	10 (30)	HG.CAST-(D9Mit249-D9Mit133)N(6)	HG9	9.1–84.2
Feml2	9	20 (48)	HG.CAST-(D9Mit249-D9Mit133)N(6)	HG9	9.1–84.2
*Carp2* Wg4 Cara2	11	46–50 (80–90)	HG.CAST-(D11Mit260-D11Mit255)N(6)	HG11	61.9–114.3
*Feml3* Carp3 Cara3	17	46–48 (70–76)	HG.CAST-(D17Mit213-D17Mit142)N(6)	HG17	14.8–77.3

QTL, quantitative trait locus; MMU, mouse chromosome; LOD, log of the odds
^a QTL MGI [59] nomenclature. Q1Ucd1-w26 never received an official MGI name, because it only reached a suggestive level of significance; hg modifier QTL are in bold [24].
^b Mbp position according to the August 2005 mm7 UCSC [28] genome assembly (NCBI Build 35), peak LOD from [24].
^c In the linkage analysis performed in [24], the peak location for Wg2, Carp1, Cara1 and Feml1 was 59–63 cM (115–120 Mbp) in hg/hg F₂ mice and 78–83 cM (135–150 Mbp) in +/+ F₂ mice.
^d Full congenic name consists of three parts: 1. B6.CAST, indicates the recipient strain is B6 and the donor strain is CAST; HG.CAST, indicates the recipient strain is HG and the donor strain is CAST; 2. markers defining the minimal congenic interval; 3. the number of backcrosses used for speed congenic development.
^e Represents the minimum genomic region spanned by CAST donor alleles.

ISSN: 1471-2164