Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains

Farber, Charles R; Corva, Pablo M; Medrano, Juan F

doi:10.1186/1471-2164-7-102

BMC Genomics

Table 2 Body length and adiposity phenotypes of B6.CAST and HG.CAST MMU2 speed congenic strains

From: Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains

Strain	Sex	N	NA (cm)	Tail (cm)	GFP (g)	FFP (g)	MFP (g)	RFP (g)	TF (g)	AI (%)	BMI
B6C	M	29	9.1 ± 0.04	7.9 ± 0.04	0.344 ± 0.008	0.229 ± 0.006	0.183 ± 0.006	0.066 ± 0.002	0.823 ± 0.018	3.1 ± 0.1	31.6 ± 0.3
B62P	M	20	9.2 ± 0.05	7.9 ± 0.04	0.309 ± 0.010	0.235 ± 0.007	0.178 ± 0.007	0.045 ± 0.003	0.768 ± 0.023	2.9 ± 0.1	30.8 ± 0.4
B62PM	M	24	9.1 ± 0.05	7.8 ± 0.05	0.304 ± 0.010	0.222 ± 0.008	0.173 ± 0.007	0.046 ± 0.003	0.746 ± 0.024	2.9 ± 0.1	31.3 ± 0.4
B62M	M	27	8.9 ± 0.07	7.4 ± 0.06	0.294 ± 0.014	0.239 ± 0.010	0.214 ± 0.009	0.066 ± 0.004	0.813 ± 0.032	3.2 ± 0.1	31.4 ± 0.5
B62D	M	21	9.2 ± 0.06	7.1 ± 0.06	0.259 ± 0.013	0.177 ± 0.009	0.154 ± 0.009	0.038 ± 0.004	0.629 ± 0.030	2.6 ± 0.1	28.9 ± 0.5
B6C	F	39	8.6 ± 0.03	7.6 ± 0.03	0.166 ± 0.007	0.202 ± 0.005	0.141 ± 0.005	0.027 ± 0.002	0.536 ± 0.016	2.6 ± 0.1	27.7 ± 0.3
B62P	F	23	8.6 ± 0.05	7.8 ± 0.04	0.134 ± 0.010	0.224 ± 0.007	0.148 ± 0.007	0.023 ± 0.003	0.528 ± 0.022	2.7 ± 0.1	26.1 ± 0.4
B62PM	F	20	8.4 ± 0.05	7.4 ± 0.05	0.139 ± 0.011	0.214 ± 0.008	0.154 ± 0.007	0.023 ± 0.003	0.530 ± 0.025	2.8 ± 0.1	26.9 ± 0.4
B62M	F	32	8.4 ± 0.05	7.3 ± 0.05	0.153 ± 0.010	0.204 ± 0.007	0.165 ± 0.007	0.029 ± 0.003	0.551 ± 0.023	2.8 ± 0.1	27.9 ± 0.4
B62D	F	23	8.7 ± 0.06	7.0 ± 0.06	0.110 ± 0.013	0.157 ± 0.009	0.135 ± 0.009	0.019 ± 0.004	0.420 ± 0.029	2.2 ± 0.1	25.0 ± 0.5
HGC	M	31	10.2 ± 0.05	8.0 ± 0.05	0.477 ± 0.013	0.317 ± 0.008	0.297 ± 0.010	0.110 ± 0.005	1.201 ± 0.030	3.3 ± 0.1	35.0 ± 0.4
HG2P	M	18	10.1 ± 0.07	8.2 ± 0.07	0.428 ± 0.019	0.326 ± 0.011	0.227 ± 0.014	0.069 ± 0.007	1.051 ± 0.043	3.1 ± 0.1	32.8 ± 0.5
HG2PM	M	29	10.1 ± 0.05	8.0 ± 0.05	0.439 ± 0.014	0.303 ± 0.008	0.244 ± 0.010	0.082 ± 0.005	1.068 ± 0.031	3.1 ± 0.1	33.7 ± 0.4
HG2M	M	31	10.1 ± 0.05	7.4 ± 0.05	0.469 ± 0.014	0.346 ± 0.008	0.306 ± 0.010	0.136 ± 0.005	1.260 ± 0.032	3.6 ± 0.1	33.9 ± 0.4
HGC	F	23	9.6 ± 0.06	7.8 ± 0.06	0.369 ± 0.015	0.305 ± 0.009	0.268 ± 0.011	0.076 ± 0.005	1.020 ± 0.035	3.9 ± 0.1	28.2 ± 0.4
HG2P	F	16	9.2 ± 0.07	7.8 ± 0.07	0.248 ± 0.018	0.311 ± 0.011	0.200 ± 0.013	0.044 ± 0.006	0.804 ± 0.041	3.4 ± 0.1	28.3 ± 0.5
HG2PM	F	36	9.4 ± 0.04	7.7 ± 0.04	0.277 ± 0.012	0.265 ± 0.007	0.208 ± 0.009	0.046 ± 0.004	0.797 ± 0.027	3.2 ± 0.1	27.8 ± 0.3
HG2M	F	28	9.6 ± 0.05	7.2 ± 0.05	0.329 ± 0.014	0.269 ± 0.009	0.247 ± 0.010	0.064 ± 0.005	0.909 ± 0.033	3.4 ± 0.1	29.3 ± 0.4

NA, nasal-anal body length; Tail, tail length; GFP, gonadal fat pad; FFP, femoral fat pad; MFP, mesenteric fat pad; RFP, retroperitoneal fat pad; TF, summed weight of four fat pads; AI, adiposity index (TF/body weight*100) and BMI, body mass index (body weight at sacrifice/NA² *100). Values are expressed as LSMEANS ± SEM. LSMEANS in bold are significantly different than the respective control after Bonferroni correction (B6 (critical P < 0.00625) or HG (P < 0.00833)) within each sex.

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com