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Table 1 LET-756-interacting proteins identified by screening Y2H C. elegans libraries. Bait used was DB-LET-756. Sequences of AD-interactor clones are in (58). Clones were assigned scores for LacZ expression, growth on plates lacking histidine but containing 20 or 40 mM 3-amino triazol (3-AT) and in addition, growth on plates lacking uracil (URA) for the C. elegans libraries

From: Direct and heterologous approaches to identify the LET-756/FGF interactome

Interactor (sequence name)

Gene name

Human ortholog(s)

LacZ

3-AT 20 mM

3-AT40 mM

URA

Library

AD-C38D4.6

pal-1

CDX4 (Caudal-type homeobox protein 4)

++

+

-

-

cDNA

AD-C47E8.5

daf-21

HSP90 family

-

++

+

-

cDNA

AD-T01C3.6

rps-16

RPS16 (40S ribosomal protein S16)

+/-

++

-

-

cDNA

AD-T07C4.1

-

UMPS (UMP-synthase)

-

+/-

-

++

cDNA

AD-C15C8.3

-

CTSE (Cathepsin E precursor)

+/-

+

-

-

cDNA

AD-C15C6.2b

C15C6.2

-

-

+

+

-

cDNA

AD-M18.1

col-129

COL4A5 (Collagen alpha 5(IV) chain precursor)

+/-

+

+/-

-

cDNA

AD-F35A5.4

-

KRTAP10-4 (Keratin-associated protein 10-4)

+

-

-

-

AD-ORFeome

AD-F46A9.4

skr-2

SKP1A (S-phase kinase-associated protein 1A)

+/-

++

-

-

AD-ORFeome