Figure 2

Representation of the phosphorylation and redox control of DNA binding in bZIP dimers. Red-dotted monomers contain C19, whereas blue-dotted monomers contain either S19 or Y19. C-C type dimers are very sensitive to oxidative stress and cannot bind to DNA under these conditions. C-S and C-Y dimers are moderately sensitive to oxidative stress. Furthermore, C-S and C-Y dimers can be phosphorylated at S19 or Y19 to totally abolish DNA binding. S-S and S-Y dimers also totally abolish DNA binding when phosphorylated at any of the S19 or Y19 residues. Phosphorylation behaves dominantly. To simplify the graph, we excluded A19 monomers and dimers. A-A type dimers are neither controlled by redox nor by phosphorylation. S-A type dimers are controlled by phosphorylation. No C-A or Y-A type dimers have been observed, see [19].