Statistics of predicted interactions in Plasmodium (a). In each bin, we calculated the mean expectation value of domain interactions that govern the underlying protein interactions. In particular we obtain a significant correlation (r = 0.22, P < 10-5, ρ = 0.34, P < 10-5). Error bars correspond to standard deviations in each bin. (b) In the same way, we calculated the mean functional homogeneity, a measure that reflects the probability that GO terms of interacting proteins are similar. In particular, we find a statistically significant correlation (r = 0.45, P < 10-5, ρ = 0.52, P < 10-5). (c) Determining the frequency of interactions which are fully conserved in the organisms S. cerevisiae, D. melanogaster and H. sapiens we find a strong tendency toward evolutionary conservation of predicted interactions with elevated level of confidence.