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Table 2 Domain interactions in predictions of protein interactions in Plasmodium. Predicting protein interactions by their highest scoring domain interaction in P. falciparum we find the following 20 most frequent domain interactions. N refers to the domain interactions occurrence in the predicted set, % sl depicts the percentage of self protein interactions, and E is the expectation value of the underlying domain interaction.

From: Topology and weights in a protein domain interaction network – a novel way to predict protein interactions

domain description domain description N % sl E
PF00076 rrm1 PF01423 LSM 137 - 14.5
PF00227 proteasome PF00227 proteasome 120 12.5 103.1
PF01423 LSM PF01423 LSM 120 12.5 387.1
PF00005 ABC transporter PF00005 ABC transporter 83 16.5 4.9
PF00097 zf-C3HC4 PF00240 ubiquitin 74 - 5.7
PF00076 rrm1 PF00076 rrm1 56 28.7 14.5
PF00022 actin PF00022 actin 55 18.1 8.5
PF00125 histone PF00125 histone 36 22.1 11.6
PF01423 LSM PF06220 zf-U1 30 - 20.3
PF02953 Tim10/DDP zinc finger PF00153 mitochondrial carrier 30 - 6.6
PF00097 zf-C3HC4 PF01283 Ribosomal protein S 24 - 3.0
PF00097 zf-C3HC4 PF01775 Ribosomal L18ae 24 - 7.3
PF00097 zf-C3HC4 PF00833 Ribosomal S17 24 - 3.6
PF00097 zf-C3HC4 PF00827 Ribosomal L15 24 - 3.2
PF00118 TCP-1/cpn60 chaperonin PF00118 TCP-1/cpn60 chaperonin 23 34.8 17.9
PF00928 Adaptor complexes PF01217 Clathrin adaptor 20 - 21.7
PF00076 rrm1 PF01974 tRNA intron endonuclease 18 - 3.0
PF00076 rrm1 PF06220 zf-U1 18 - 6.2
PF01602 Adaptin N terminal region PF01217 Clathrin adaptor complex 16 - 9.2
PF00125 histone PF00956 Nucleosome assembly protein 16 - 14.5