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Table 2 Domain interactions in predictions of protein interactions in Plasmodium. Predicting protein interactions by their highest scoring domain interaction in P. falciparum we find the following 20 most frequent domain interactions. N refers to the domain interactions occurrence in the predicted set, % sl depicts the percentage of self protein interactions, and E is the expectation value of the underlying domain interaction.

From: Topology and weights in a protein domain interaction network – a novel way to predict protein interactions

domain

description

domain

description

N

% sl

E

PF00076

rrm1

PF01423

LSM

137

-

14.5

PF00227

proteasome

PF00227

proteasome

120

12.5

103.1

PF01423

LSM

PF01423

LSM

120

12.5

387.1

PF00005

ABC transporter

PF00005

ABC transporter

83

16.5

4.9

PF00097

zf-C3HC4

PF00240

ubiquitin

74

-

5.7

PF00076

rrm1

PF00076

rrm1

56

28.7

14.5

PF00022

actin

PF00022

actin

55

18.1

8.5

PF00125

histone

PF00125

histone

36

22.1

11.6

PF01423

LSM

PF06220

zf-U1

30

-

20.3

PF02953

Tim10/DDP zinc finger

PF00153

mitochondrial carrier

30

-

6.6

PF00097

zf-C3HC4

PF01283

Ribosomal protein S

24

-

3.0

PF00097

zf-C3HC4

PF01775

Ribosomal L18ae

24

-

7.3

PF00097

zf-C3HC4

PF00833

Ribosomal S17

24

-

3.6

PF00097

zf-C3HC4

PF00827

Ribosomal L15

24

-

3.2

PF00118

TCP-1/cpn60 chaperonin

PF00118

TCP-1/cpn60 chaperonin

23

34.8

17.9

PF00928

Adaptor complexes

PF01217

Clathrin adaptor

20

-

21.7

PF00076

rrm1

PF01974

tRNA intron endonuclease

18

-

3.0

PF00076

rrm1

PF06220

zf-U1

18

-

6.2

PF01602

Adaptin N terminal region

PF01217

Clathrin adaptor complex

16

-

9.2

PF00125

histone

PF00956

Nucleosome assembly protein

16

-

14.5