Table 2 ILV6 targets. The putative targets of a novel regulator gene, ILV6, in the "group 2" loci from [4]. The list includes five additional targets not previously identified.
From: Causal inference of regulator-target pairs by gene mapping of expression phenotypes
Novel | Target Gene | QTG Score | QTL Score | Description |
|---|---|---|---|---|
Y | YLR040C | 49 | 35 | hypothetical protein |
Y | STE3 | 43 | 36 | Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR, |
N | LEU4 | 29 | 7 | Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway |
N | ILV3 | 24 | 7 | Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids |
N | ILV2 | 22 | 7 | Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control |
N | SNZ1 | 20 | 6 | Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Snolp and with Yhrl98p, perhaps as a multiprotein complex containing other Snz and Sno proteins |
N | ALD5 | 20 | 7 | Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed |
N | BAT1 | 19 | 9 | Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase |
N | OAC1 | 19 | 10 | Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family |
N | YLR089C | 18 | 4 | Putative alanine transaminase (glutamic pyruvic transaminase) |
N | DIC1 | 18 | 7 | Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix |
N | BAP2 | 17 | 9 | High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains |
N | YOR225W | 16 | 10 | Â |
Y | CTF13 | 15 | 4 | Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis |
Y | SN01 | 15 | 4 | Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snzlp with Snolp serving as the glutaminase |
N | ISU2 | 14 | 5 | Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable |
Y | PMI40 | 9 | 4 | Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation |