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Table 1 Annotation and biological pathway analysis.

From: Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms

Protein Classifications and Pathways

Number of Overlapping Genes

Random Overlapping p value

PANTHER™ Protein Classification System ( p < 0.001)

  

Luminal A subtype

  

Fatty acid metabolism

11

1.22E-04

Steroid hormone-mediated signaling

5

8.09E-04

Basal-like subtype

  

Cell cycle

55

2.50E-13

Cell proliferation and differentiation

40

9.62E-08

Protein phosphorylation

34

2.31E-07

B-cell-and antibody-mediated immunity

17

2.63E-07

Cell cycle control

25

2.38E-06

Jubilant PathArt™ Pathways ( p < 0.01)

  

Luminal A subtype

  

ER Signaling Pathway

6

2.80E-04

Retinoic Acid Signaling Pathway

4

4.46E-04

Nucleotide Excision Repair Pathway

4

1.92E-03

IL6 Signaling Pathway

6

4.73E-03

EGF Signaling Pathway

7

4.92E-03

Basal-like subtype

  

p21 Mediated Pathway

15

9.14E-13

G1-S Checkpoint Pathway

10

1.03E-08

FAS Mediated Pathway

3

7.49E-04

p53 Signaling Pathway

7

8.45E-04

  1. Upper part: The most significant biological processes (PANTHER™ Protein Classification System) over-represented by the luminal A subtype and the basal-like subtype (p < 0.001, top 5 are shown); Lower part: The most significant cellular pathways (PathArt™) over-represented by the luminal A subtype and the basal-like subtype (p < 0.01).