Table 4 List of biological processes whose regulation involves transcription factors with putative target sites on Alu. Those transcription factors that were experimentally found to bind to Alu (see Table 2) are in bold. These reported binding events involved specific Alu sequences, and were not based on genome-wide screening.
Biological Porcess | BM(TFs) |
|---|---|
Nuclear factors and stress response | ER.01–2 (see table 2), RAR.01 (table 2), LXRE.01, GC.01 (SP1) |
Hematopoietic differentiation | GFI.01 ( Gfi-1 *) LYF1.01 ( ZNF1A1 ), GATA3.02 ( GATA3 ), OC2.01 (ONECUT2), GATA2.01(GATA2) |
Heart development/Muscle development | PITX2*, NKX25.01 (Nkx2.5*), LUN01_01 (LUN1) MEF2.01–04 (MEF2A,B,C,D), RSRFC4.01/02 |
Brain and CNS development: | PAX6.01 (PAX6),PAX4.01 (PAX4), OTX2.02 (OTX2), NRL.01 (NRL), BRN2.03, (POU3F2), BRN3.01(POU3F3) |
Eye development | PITX2.Q2 ( PITX2 )*,PAX6.01 ( PAX6 ), SIX3.01(SIX3) |
Pancreas developments | PAX6.01( PAX6 ), PDX1.01 |
Embryonic development | GSC.01 (GSCL) |
Sterol biosynthesis | SREBP.03 (SREBPF3) |
Interferon | IRF1.01 (IRF1) IRF2.01,(IRF2), HEN1.01, HEN1.03 (TCF1,TCF2) |