Table 1 Cancer genes with codons inserted/deleted in chimpanzee. Summary of chimpanzee cancer genes showing inserted/deleted codons with respect to the human sequence. The number of inserted/deleted codons, the amino acid change and whether the insertion/deletion occurred in trinucleotide expanded regions is shown. The status of this codon in human is also indicated.
From: Comparative analysis of cancer genes in the human and chimpanzee genomes
Gene | Codons | Residues inserted | Human status |
|---|---|---|---|
Codons inserted in chimpanzee | |||
CCNE1 | 1 | S | - |
FANCC | 1 | Q (in polyQ repeat) | Polymorphic |
FGFR1 | 1 | D (in polyD repeat). | - |
HOXD11 | 1 | G (in polyG repeat) | - |
HSPCA1 | 1 | E (in polyE repeat) | - |
MLLT2 | 1 | S | - |
MLLT3 | 2 | SS (in polyS repeat) | Polymorphic |
MN1 | 4+1 | QQQQ and Q (in polyQ repeats) | - |
PML | 2 | GF | - |
Codons inserted in human | |||
AF15Q14 | 1 | R | - |
ASPSCR1 | 2 | ER (in polyER repeat) | Polymorphic |
ATF1 | 1 | A | - |
DEK | 1 | E (in polyE repeat) | Polymorphic |
DING | 1+2 | L and RD (in polyRD repeat) | - |
EP300 | 3 | MQQ (2 repeats in human, 1 in chimpanzee) | - |
LMO2 | 1 | G (in polyG repeat) | - |
MLLT2 | 1 | S (in polyS repeat) | - |
MYST4 | 2+1 | EE and E (in polyE repeats) | Polymorphic |
NUMA1 | 4 | AAIG | - |
SMO | 1 | L (in polyL repeat) | - |
ZNF384 | 1 | Q (in polyQ repeat) | Polymorphic |