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Table 2 HSP90 family of genes present on the genomes of 32 species, and their chromosomal location, intron/exon structure, molecular mass, signal peptide and prediction of genes that are functional.

From: Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

Gene namea Accession numberb Chrom. locationc Exon nod a.a.lengthe Mass (kDa)f Functiong
  mRNA a.a.      
ARCHAEA        
Methanosarcina mazei        
(MMA)NP_634445.1 NC_003901.1 NP_634445.1 N/A+ 1 982 114.6 F
BACTERIA        
Streptomyces coelicolor        
(SCO)HTPG1 NC_003888.3 NP_631561.1 N/A+ 1 638 71.6 F
(SCO)HTPG2 NC_003888.3 NP_625688.1 N/A- 1 615 66.7 F
Bacteroides fragilis        
(BFR)HTPG1 NC_006347.1 YP_099692.1 N/A- 1 681 78.0 F
(BFR)HTPG2 NC_006347.1 YP_097520.1 N/A+ 1 588 67.3 F
Gloeobacter violaceus        
(GVI)HTPG1 NC_005125.1 NP_924760.1 N/A+ 1 614 70.3 F
Bacillus subtilis        
(BSU)HTPG1 NC_000964.2 NP_391861.1 N/A- 1 626 72.3 F
Wolbachia endosymbiont        
(WEN)HTPG1 NC_002978.6 NP_966987.1 N/A+ 1 635 72.7 F
Bordetella pertussis        
(BPE)HTPG1 NC_002929.2 NP_878979.1 N/A+ 1 635 71.2 F
Geobacter sulfurreducens        
(GSU)HTPG1 NC_002939.4 NP_953436.1 N/A+ 1 650 73.7 F
Helicobacter pylori        
(HPY)HTPG1 NC_000921.1 NP_222917.1 N/A+ 1 621 71.1 F
Escherichia coli        
(ECO)HTPG1 NC_000913.2 NP_415006.1 N/A+ 1 624 71.4 F
Borrelia burgdorferi        
(BBU)HTPG1 NC_001318.1 NP_212694.1 N/A- 1 650 75.4 F
FUNGI        
Saccharomyces cerevisiae        
(SCE)HSP90A1 K01387.1 AAA02743.1 16- 1 (1) 709 81.4 F
(SCE)HSP90A2 M26044.1 AAA02813.1 13+ 1 (1) 705 80.9 F
Cryptococcus neoformans        
(CNE)HSP90A1 XM_568451.1 XP_568451.1 13- 6 700 79.3 F
(CNE)HSP90B1 XM_571124.1 XP_571124.1 5+ 11 758 (780, H) 85.5 (87.8) F
Encephalitozoon cuniculi        
(ECU)HSP90A1 NC_003229.1 NP_584635.1 2+ 1 690 79.0 F
Neurospora crassa        
(NCR)HSP90A1 AABX01000271.1 EAA32062.1 5+ 2 705 80.2 F
PROTISTA        
Plasmodium falciparum        
(PFA)HSP90A1 NC_004328.1 NP_704028.1 7+ 2 745 86.2 F
(PFA)HSP90B1 NC_004316.1 NP_701576.1 12- 1 793 (821, H) 91.6 (95.0) F
Dictyostelium discoideum        
(DDI)HSP90A1 AAFI01000009.1 EAL73152.1 1- 3 700 79.9 F
(DDI)HSP90B1 AAFI01000066.1 EAL67255.1 3- 2 739 (767, H) 84.1 (87.1) F
Entamoeba histolytica        
(EHI)HSP90A1 AAFB01000333.1 EAL47778.1 (Sca 00092+) 1 718 83.0 F
(EHI)HSP90A2 AAFB01000334.1 EAL47746.1 (Sca 00092+) 1 718 83.0 F
(EHI)HSP90A3 AAFB01000781.1 EAL44230.1 (Sca 00284+) 2 702 81.1 F
(EHI)HSP90B1 AAFB01000726.1 EAL44584.1 (Sca 00256-) 1 695 (711, H) 79.5 (81.2) F
Trypanosoma cruzi        
(TCR)HSP90A1 AAHK01000382.1 EAN93041.1 N/A 1 704 80.7 F
(TCR)HSP90A2 AAHK01000690.1 EAN89940.1 N/A 1 704 80.7 F
(TCR)HSP90A3 AAHK01002401.1 EAN82629.1 N/A 1 704 80.7 F
(TCR)HSP90B1 AAHK01000131.1 EAN96800.1 N/A 1 740 (762, H) 84.7 (87.0) F
PLANTAE        
Arabidopsis thaliana        
(ATH)HSP90A1 NM_124642.2 NP_200076.1 5+ 4 (4) 705 81.2 F
(ATH)HSP90A2 NM_124985.3 NP_200414.1 5- 3 (3) 699 80.1 F
(ATH)HSP90A3 NM_124983.3 NP_200412.1 5+ 3 (3) 699 80.0 F
(ATH)HSP90A4 NM_124982.2 NP_200411.1 5+ 3 (3) 699 80.1 F
(ATH)HSP90B1 NM_118552.2 NP_194150.1 4- 15 (15) 800 (823, H) 91.5 (94.2) F
(ATH)HSP90C1 NM_126439.2 NP_178487.1 2+ 19 (19) 756 (780, H) 86.2 (88.7) F
(ATH)HSP90C2 NM_111656.2 NP_187434.1 3+ 21 (21) 778 (803, H) 88.2 (91.0) F
Oryza sativa        
(OSA)HSP90A1P XM_483191.1 XP_483191.1 8- 3 699 80.2 F
(OSA)HSP90A2P XM_470993.1 XP_470993.1 4+ 3 703 80.2 F
(OSA)HSP90A3P AP005392.3 BAD33406.1 9- 1 699 80.2 F
(OSA)HSP90A4P AP005392.3 BAD33409.1 9- 1 699 80.2 F
(OSA)HSP90A5PNP (OSA)HSP90A5NN* (OSA)HSP90A5PN* 9- 1 437*   P
(OSA)HSP90B1 AB037681.1 BAA90487.1 6- 15 (15) 791 (810, H) 90.6 (92.8) F
(OSA)HSP90C1 XM_483065.1 XP_483065.1 8- 19 (19) 763 (785, H) 86.3 (88.3) F
(OSA)HSP90C2 AK073817.1 (OSA)HSP90C2PN 9- 14 (17) 785 (811, H) 89.0 (91.5) F
Chlamydomonas reinhardtii        
(CRE)HSP90A1 Schroda (2004)   (Sca 2397) 8 705 80.7 F
(CRE)HSP90B1 Schroda (2004)*   (Sca 2084, 1758) ≥11 736*   F
(CRE)HSP90C1 AY705371.1 AAU10511.1 (Sca 6) 10 756 (810, H) 84.2 (89.3) F
INVERTEBARATE        
Drosophila melanogaster        
(DME)HSP90A1 NM_079175.2 NP_523899.1 3L+ 63B11 1 (2) 717 81.9 F
(DME)HSP90B1 NM_143344.2 NP_651601.1 3R+ 98B6 5 (5) 767 (787, H) 88.1 (90.2) F
(DME)TRAP1 NM_058091.3 NP_477439.2 2R- 42C1 3 (3) 673 (691, N) 74.7 (78.0) F
Drosophila pseudoobscura        
(DPS)HSP90A1P NM_079175.2 NP_523899.1 XR- 1 717 81.8 F
(DPS)HSP90B1P CM000070.1 EAL27390.1 2- 5 772 (792, H) 88.4 (90.5) F
(DPS)TRAP1P CM000071.1 EAL26542.1 3- 3 644 (688, N) 74.8 (78.1) F
Anopheles gambiae        
(AGA)HSP90A1P XM_308800.2 XP_308800.2 2L- 2 689 78.3 F
(AGA)HSP90A2P XM_308799.1 XP_308799.1 2L+ 3 720 82.1 F
(AGA)HSP90A3PNP (AGA)HSP90A3N N* (AGA)HSP90A3PN* 2L+ 2 380*   P
(AGA)HSP90B1NP (AGA)HSP90B1N N (AGA)HSP90B1PN 2R- 2 778 (800, H) 88.9 (91.3) F
(AGA)TRAP1NP (AGA)TRAP1N N (AGA)TRAP1PN 3L+ 3 677 (713, H) 76.8 (80.6) F
Apis mellifera        
(AME)HSP90A1P XM_392456.2 XP_392456.2 (Group 7-) 3 (3) 700 80.7 F
(AME)HSP90A2P XM_395168.2 XP_395168.2 (Group 1-) 3 (3) 699 80.5 F
(AME)HSP90B1P XM_395614.2 XP_395614.2 (Group 8-) 5 (5) 766 (786, H) 88.5 (90.8) F
(AME)TRAP1P XM_623363.1 XP_623366.1 (Group 6-) 13 (13) 668 (693, N) 76.7 (79.6) F
Caenorhabditis elegans        
(CEL)HSP90A1 NM_074225.2 NP_506626.1 5+ 4 (5) 702 80.2 F
(CEL)HSP90B1 NM_069679.2 NP_502080.1 4+ 5 (5) 737 (760, H) 84.6 (87.1) F
(CEL)TRAP1 NM_171188.2* NP_741219.1* 3- 9 (9) 464*   F
Strongylocentrotus purpuratus        
(SPU)HSP90A1 XM_777937.1* XP_783030.1* N/A- ≥ 8 (9) 510*   F
(SPU)HSP90A2 XM_782798.1* XP_787891.1* N/A+ ≥ 5 319*   F
(SPU)HSP90B1 NM_214643.1 NP_999808.1 N/A+ 17 784 (806, H) 90.0 (92.3) F
(SPU)TRAP1 XM_778412.1 XP_783505.1 N/A+ 15 665 (691, N) 75.5 (78.6) F
VERTEBRATE        
Homo sapiens        
Chen et al.A (2005)        
Gallus gallus        
(GGA)HSP90AA1 X07265.1 CAA30251.1 5- 8 728 84.1 F
(GGA)HSP90AB1 XM_444655.1 XP_444655.1 3- 11 725 83.5 F
(GGA)HSP90B1 NW_060209.1 NP_989620.1 1- 18 774 (795, H) 89.5 (91.6) F
(GGA)TRAP1 NW_060530.1 XP_414963.1 14- 18 663 (699, N) 75.5 (79.5) F
Danio rerio        
(DRE)HSP90AA1 AF068773.1 AAC21567.1 20- 10 (10) 726 83.6 F
(DRE)HSP90AA2NP (DRE)HSP90AA2NN (DRE)HSP90AA2PN 20- 10 734 84.7 F
(DRE)HSP90AA3PNP (DRE)HSP90AA3NN* (DRE)HSP90AA3PN* 7+ 12 838*   P
(DRE)HSP90AA4PNP (DRE)HSP90AA4NN* (DRE)HSP90AA4PN* 7+ 3 417*   P
(DRE)HSP90AB1 AF042108.1 AAB96969.1 7- 7 (7) 725 83.4 F
(DRE)HSP90B1 BC063951.1 AAH63951.1 4+ 18 (18) 772 (793, H) 88.9 (91.3) F
(DRE)HSP90B2NP (DRE)HSP90B2NN (DRE)HSP90B2PN 4+ 18 773 (794, H) 89.1 (91.4) F
(DRE)TRAP1NP (DRE)TRAP1N* (DRE)TRAP1N* 23+ ≥8 414*   F
Ciona intestinalis        
(CIN)HSP90A1 AK115284.1 AK115284.1PN (Sca 118+) 11 (12) 726 83.3 F
(CIN)HSP90B1NP (CIN)HSP90B1NN* (CIN)HSP90B1PN* (Sca 963-) ≥15 732*   F
(CIN)HSP90B2PNP (CIN)HSP90B2NN* (CIN)HSP90B2PN* (Sca 462-) ≥2 119*   P
(CIN)TRAP1NP (CIN)TRAP1N (CIN)TRAP1N (Sca 143+) 13 687 (719, N) 77.9 (81.5) F
  1. a P predicted by genome annotation; NP predicted in this study. The abbreviations of species names in parenthesis are in Table 3. The genes with their nomenclatures ended with "P" are putative pseudogenes.
  2. bN new sequences identified/deduced in this study and available at Additional File 1. The sequences marked with "*" are not full-length.
  3. c Chromosomal location. + forward strand; – reverse strand. The numbers/letters are the chromosome numbers/letters, and N/A indicates unavailability of the chromosome number and Sca indicates Scaffold.
  4. d Total number of exons in coding regions. The numbers in parenthesis include exons in untranslated regions.
  5. e length of mature polypeptide with that of precursor and prediction method (Hidden Markov models, H; Neural networks, N) in parenthesis. The sequences marked "*" are incomplete, or from putative pseudogenes, and their mature polypeptides are not predicted.
  6. f molecular mass of mature polypeptide with that of precursor in parenthesis.
  7. g F – functional genes predicted by transcript and domain identification. P – putative pseudogenes.