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Table 4 Signature sequences detected in each subfamily or in particular subfamily combinations. The numbers in parenthesis following the signature sequence indicate the residue numbers in the corresponding reference sequence. HSP90B has no unique signature sequence but the combination of these conserved motifs can distinguish it from other family members. The alignment is in Figure 1.

From: Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

Subfamily

Signature sequence

Reference

HSP90AA

LIP (80–82), GDKKKK (272–277), TSASG (467–471), VSLKDYCT (475–482), QEEKK (561–565), EDD (701–703), MPP (717–719)

(HSA)HSP90AA1

HSP90AB

LKID (residues 71–74)

(HSA)HSP90AB1

HSP90A

SLIINT (31–36), NNLGTIA (105–111), SMIGQFGVGFYS (129–140), AGG (166–168), RGT (182–184), KHFSVEGQLEF (327–337), VKK (417–419), HED (450–452), TGE (495–497), IDEY (525–528), QALRD (617–621)

(HSA)HSP90AA1

HSP90B

FLREL (residues 100–104), IGQFGVGFYS (191–201), LPLNVSRE (442–449)

(HSA)HSP90B1

HSP90C

YQAEV (81–85), EVFLREL (101–107), LIGQFGVGFYSAFLV (193–207), DPLA (361–364), LYVKRVFISD (403–412), PRYL (420–423), DLPLNVSREILQESRIVR (434–451), APF (548–560)

(ATH)HSP90C1

TRAP

LLDIVA (97–102), NLGTIARSGS (171–180), IIGQFGVGFY (197–206), PLNLSRE (397–403), SPY (511–513)

(HSA)TRAP1

HTPG

No signature sequence

 

HSP90A+B

VRRV (365–368), GMT (97–99)

(HSA)HSP90AA1

HSP90B+C

LPLNVSRE (442–449)

(HSA)HSP90B1

HSP90A+B+C

FLREL (44–48), VDS (389–391), LPLN (394–397)

(HSA)HSP90AA1

HSP90A+B+C+TRAP+Group A

IGQFGVGFY (131–139), PLN (395–397)

(HSA)HSP90AA1

HSP90A+B+C+TRAP+HTPG

Y (38), REL (46–48), N (51), D (54), G (95), G (97), GQFG (132–135), G (183), P (379), SRE (399–401)

(HSA)HSP90AA1