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Table 4 Signature sequences detected in each subfamily or in particular subfamily combinations. The numbers in parenthesis following the signature sequence indicate the residue numbers in the corresponding reference sequence. HSP90B has no unique signature sequence but the combination of these conserved motifs can distinguish it from other family members. The alignment is in Figure 1.

From: Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

Subfamily Signature sequence Reference
HSP90AA LIP (80–82), GDKKKK (272–277), TSASG (467–471), VSLKDYCT (475–482), QEEKK (561–565), EDD (701–703), MPP (717–719) (HSA)HSP90AA1
HSP90AB LKID (residues 71–74) (HSA)HSP90AB1
HSP90A SLIINT (31–36), NNLGTIA (105–111), SMIGQFGVGFYS (129–140), AGG (166–168), RGT (182–184), KHFSVEGQLEF (327–337), VKK (417–419), HED (450–452), TGE (495–497), IDEY (525–528), QALRD (617–621) (HSA)HSP90AA1
HSP90B FLREL (residues 100–104), IGQFGVGFYS (191–201), LPLNVSRE (442–449) (HSA)HSP90B1
HSP90C YQAEV (81–85), EVFLREL (101–107), LIGQFGVGFYSAFLV (193–207), DPLA (361–364), LYVKRVFISD (403–412), PRYL (420–423), DLPLNVSREILQESRIVR (434–451), APF (548–560) (ATH)HSP90C1
TRAP LLDIVA (97–102), NLGTIARSGS (171–180), IIGQFGVGFY (197–206), PLNLSRE (397–403), SPY (511–513) (HSA)TRAP1
HTPG No signature sequence  
HSP90A+B VRRV (365–368), GMT (97–99) (HSA)HSP90AA1
HSP90B+C LPLNVSRE (442–449) (HSA)HSP90B1
HSP90A+B+C FLREL (44–48), VDS (389–391), LPLN (394–397) (HSA)HSP90AA1
HSP90A+B+C+TRAP+Group A IGQFGVGFY (131–139), PLN (395–397) (HSA)HSP90AA1
HSP90A+B+C+TRAP+HTPG Y (38), REL (46–48), N (51), D (54), G (95), G (97), GQFG (132–135), G (183), P (379), SRE (399–401) (HSA)HSP90AA1