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Table 1 Frequency of upstream AUGs and ORFs.

From: Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides

 

Human

Mouse

Number of mRNA sequences in initial dataset (1)

16504

11291

Number of mRNA sequences containing > 1 uAUG (2)

9531

6352

Total number of uAUGs (3)

35599

24308

Number of mRNA sequences containing > 1 uORF (4)

4557

2820

Total number of uORFs (5)

8216

5487

Number of mRNA sequences containing > 1 uORF after removal of duplicates (6)

3924

2795

Total number of uORFs after removal of duplicates (7)

7138

5430

Number of mRNA sequences containing > 1 uORF after removal of blast matches (8)

3650

2678

Total number of uORFs after removal of blast matches (9)

6454

5089

  1. Frequency of upstream AUGs and ORFs in human and mouse RefSeq mRNA sequences. Initial dataset refers to all sequences of > 60 nucleotides annotated as 5' UTRs. Numbers in parentheses indicate the corresponding stage in the filtering flowchart (figure 1).