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Table 3 Comparison of the frequency of AUGs in different contexts.

From: Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides

Context of AUG present in: Human Mouse
  Optimal Strong Weak Optimal Strong Weak
All main CDS 39.8 51.4 8.8 38.7 52.6 8.6
Conserved uORFs 24.5 44.6 30.9 24.0 42.6 30.4
Non-conserved uORFs 16.5 48.8 34.7 17.1 47.5 35.3
Main CDS of uORF genes 33.6 52.4 13.9 32.7 53.7 13.6
Short uORFs 12.3 51.2 36.5 12.6 50.0 37.4
Theoretical uAUG* 15.4 50.4 34.2 14.8 50.2 34.9
Conserved dORFS 11.8 47.4 40.8 11.0 45.2 40.8
Non-conserved dORFs 11.4 49.0 39.6 12.0 48.0 40.1
Main CDS of dORF genes 39.2 51.6 9.2 38.7 52.7 8.5
Short dORFs 8.5 48.6 42.9 8.9 47.9 43.2
Theoretical dAUG* 10.6 49.7 39.7 10.6 49.6 39.6
  1. Comparison of the frequency of AUGs in different contexts between uORFs and main ORFs. All values are expressed as percentages of the total number of AUGs in that class of ORF.
  2. *Theoretical is defined as the predicted distribution of AUG contexts if the nucleotide selection at the two critical positions was randomly selected based on the sequence composition of all UTRs in that category (i.e. 5' UTR composition for upstream AUGs, 3' UTR composition for downstream AUGs).