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Table 3 Comparison of the frequency of AUGs in different contexts.

From: Evidence for conservation and selection of upstream open reading frames suggests probable encoding of bioactive peptides

Context of AUG present in:

Human

Mouse

 

Optimal

Strong

Weak

Optimal

Strong

Weak

All main CDS

39.8

51.4

8.8

38.7

52.6

8.6

Conserved uORFs

24.5

44.6

30.9

24.0

42.6

30.4

Non-conserved uORFs

16.5

48.8

34.7

17.1

47.5

35.3

Main CDS of uORF genes

33.6

52.4

13.9

32.7

53.7

13.6

Short uORFs

12.3

51.2

36.5

12.6

50.0

37.4

Theoretical uAUG*

15.4

50.4

34.2

14.8

50.2

34.9

Conserved dORFS

11.8

47.4

40.8

11.0

45.2

40.8

Non-conserved dORFs

11.4

49.0

39.6

12.0

48.0

40.1

Main CDS of dORF genes

39.2

51.6

9.2

38.7

52.7

8.5

Short dORFs

8.5

48.6

42.9

8.9

47.9

43.2

Theoretical dAUG*

10.6

49.7

39.7

10.6

49.6

39.6

  1. Comparison of the frequency of AUGs in different contexts between uORFs and main ORFs. All values are expressed as percentages of the total number of AUGs in that class of ORF.
  2. *Theoretical is defined as the predicted distribution of AUG contexts if the nucleotide selection at the two critical positions was randomly selected based on the sequence composition of all UTRs in that category (i.e. 5' UTR composition for upstream AUGs, 3' UTR composition for downstream AUGs).
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BMC Genomics

ISSN: 1471-2164

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